An fMRI study of facial emotion processing in patients with schizophrenia
An fMRI study of facial emotion processing in patients with schizophrenia
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DOI：
10.1176/appi.ajp.159.12.1992
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发表时间：
2002-12-01
影响因子：
17.7
通讯作者：
Gur, RC
中科院分区：
文献类型：
--
作者：
Gur, RE;McGrath, C;Gur, RC
目的：精神分裂症患者存在显著的情绪加工缺陷。作者评估了精神分裂症患者在面部情绪处理过程中的脑血流反应，以验证与面部刺激的情绪相关性相关的边缘激活减少的假设。方法：14名精神分裂症患者和14名配对的对照组分别观察快乐、悲伤、愤怒、恐惧、厌恶和中性面部表情。在交叉十字准线参考条件下，被试在区分情绪效价（积极与消极）和年龄（30岁以上与30岁以下）任务之间交替进行时，采用功能磁共振成像技术测量血氧水平依赖信号的变化。结果：两组在两项任务上的表现没有差异。在这两项任务中，健康参与者的梭状回、枕叶和额叶下皮层都比静息基线条件下活跃。在情绪效价辨别任务中，杏仁核和海马体的增加大于年龄辨别任务。在精神分裂症患者中，相对于静息基线条件，在所有任务中观察到最小的焦点反应。对比患者和对照被试在情绪效价辨别任务上发现，对照被试在左杏仁核和双侧海马体中有显著更大的激活。结论：在情绪效价辨别过程中边缘区域未被激活可能解释了精神分裂症患者的情绪加工缺陷。虽然在这个临床稳定的组中，边缘补充的缺乏并没有显著损害简单效价辨别的表现，但它可能会影响更苛刻任务的表现。
Objective: Emotion processing deficits are notable in schizophrenia. The authors evaluated cerebral blood flow response in schizophrenia patients during facial emotion processing to test the hypothesis of diminished limbic activation related to emotional relevance of facial stimuli. Method: Fourteen patients with schizophrenia and 14 matched comparison subjects viewed facial displays of happiness, sadness, anger, fear, and disgust as well as neutral faces. Functional magnetic resonance imaging was used to measure blood-oxygen-level-dependent signal changes as the subjects alternated between tasks of discriminating emotional valence (positive versus negative) and age (over 30 versus under 30) of the faces with an interleaved crosshair reference condition. Results: The groups did not differ in performance on either task. For both tasks, healthy participants showed activation in the fusiform gyrus, occipital lobe, and inferior frontal cortex relative to the resting baseline condition. The increase was greater in the amygdala and hippocampus during the emotional valence discrimination task than during the age discrimination task. In the patients with schizophrenia, minimal focal response was observed for all tasks relative to the resting baseline condition. Contrasting patients and comparison subjects on the emotional valence discrimination task revealed voxels in the left amygdala and bilateral hippocampus in which the comparison subjects had significantly greater activation. Conclusions: Failure to activate limbic regions during emotional valence discrimination may explain emotion processing deficits in patients with schizophrenia. While the lack of limbic recruitment did not significantly impair simple valence discrimination performance in this clinically stable group, it may impact performance of more demanding tasks.