The involvement of the orbitofrontal cortex in the experience of regret
The involvement of the orbitofrontal cortex in the experience of regret
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DOI：
10.1126/science.1094550
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发表时间：
2004-05-21
期刊：
影响因子：
56.9
通讯作者：
Sirigu, A
中科院分区：
文献类型：
--
作者：
Camille, N;Coricelli, G;Sirigu, A
面对我们所做决定的后果可能会引发满意、解脱或后悔等情绪，这反映了我们对所获得的东西的评估，而不是做出不同的决定所获得的东西。这些情绪是由一种被称为反事实思维的认知过程调节的。通过操纵一个简单的赌博任务，我们根据受试者的预期和实际情绪影响来表征受试者的选择。正常受试者报告的情绪反应与反事实思维一致；他们选择将未来的遗憾降至最低，并从自己的情绪经历中学习。然而，眼眶额叶皮质损害的患者没有报告后悔或预期他们的选择的负面后果。眼眶前额叶皮质在调节悔恨体验方面起着重要作用。
Facing the consequence of a decision we made can trigger emotions like satisfaction, relief, or regret, which reflect our assessment of what was gained as compared to what would have been gained by making a different decision. These emotions are mediated by a cognitive process known as counterfactual thinking. By manipulating a simple gambling task, we characterized a subject's choices in terms of their anticipated and actual emotional impact. Normal subjects reported emotional responses consistent with counterfactual thinking; they chose to minimize future regret and learned from their emotional experience. Patients with orbitofrontal cortical lesions, however, did not report regret or anticipate negative consequences of their choices. The orbitofrontal cortex has a fundamental role in mediating the experience of regret.