Effect of exposure parameters on cavitation induced by low-level dual-frequency ultrasound
Effect of exposure parameters on cavitation induced by low-level dual-frequency ultrasound
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DOI：
10.1016/j.ultsonch.2006.12.016
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发表时间：
2007-09-01
影响因子：
8.4
通讯作者：
Hassan, Zahir M.
中科院分区：
文献类型：
--
作者：
Barati, Amir H.;Mokhtarl-Dizaji, Manijhe;Hassan, Zahir M.
为了量化暴露参数的治疗条件下，如声动力学治疗的影响，它是必要的初步评估的惯性空化活性在体外。在这项研究中，由低强度双频超声辐照引起的空化活性的曝光参数的依赖关系进行了研究。实验在近150 kHz和1 MHz的领域中进行的行波模式。已经表明，在恒定的超声能量下，连续超声处理的荧光强度高于脉冲模式。随着脉冲场占空比的增大，惯性空化活动增强。由两个超声场同时组合超声处理产生的空化活性显著高于由单独场产生的效应的代数和（p值< 0.05）。这项研究表明，在连续模式下同时组合双频超声声处理在低强度下产生惯性空化活性更有效。因此，可以得出结论，在这种联合超声声处理的调查可以在浅表肿瘤的声动力学治疗是有用的。(C)2007 Elsevier B.V.保留所有权利。
In order to quantify the effects of exposure parameters under therapeutic conditions such as sonodynamic therapy, it is necessary initially to evaluate the inertial cavitation activity in vitro. In this study, the dependence of cavitation activity induced by the low-level dual-frequency ultrasound irradiation on exposure parameters has been studied. Experiments were performed in the near 150 kHz and 1 MHz fields in the progressive wave mode. It has been shown that at constant ultrasound energy the fluorescence intensity for continuous sonication is higher than for pulsed mode. With increasing the duty cycle of pulsed field, the inertial cavitation activity is increased. The activity of cavitation produced by simultaneous combined sonication by two ultrasound fields is remarkably higher than the algebraic sum of effects produced by fields separately (p-value < 0.05). This study shows that simultaneous combined dual-frequency ultrasound sonication in continuous mode is more effective in producing inertial cavitation activity at low-level intensity. Therefore, it is concluded that investigations in this combined ultrasound sonication can be useful in sonodynamic therapy for superficial tumors. (C) 2007 Elsevier B.V. All rights reserved.