The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilings.
The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilings.
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DOI：
10.3389/fimmu.2013.00340
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发表时间：
2013-10-23
影响因子：
7.3
通讯作者：
Tung J
中科院分区：
文献类型：
--
作者：
Sant AJ;Chaves FA;Leddon SA;Tung J
It has been known for over 25 years that CD4 T cell responses are restricted to a finite number of peptide epitopes within pathogens or protein vaccines. These selected peptide epitopes are termed “immunodominant.” Other peptides within the antigen that can bind to host MHC molecules and recruit CD4 T cells as single peptides are termed “cryptic” because they fail to induce responses when expressed in complex proteins or when in competition with other peptides during the immune response. In the last decade, our laboratory has evaluated the mechanisms that underlie the preferential specificity of CD4 T cells and have discovered that both intracellular events within antigen presenting cells, particular selective DM editing, and intercellular regulatory pathways, involving IFN-γ, indoleamine 2,3-dioxygenase, and regulatory T cells, play a role in selecting the final peptide specificity of CD4 T cells. In this review, we summarize our findings, discuss the implications of this work on responses to pathogens and vaccines and speculate on the logic of these regulatory events.
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DOI：
10.1084/jem.184.5.1747
发表时间：
1996-11-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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影响因子：
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发表时间：
2012-05-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Jenkins MK;Moon JJ
通讯作者：
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DOI：
10.4049/jimmunol.1002276
发表时间：
2010-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
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通讯作者：
Jenkins MK
影响因子：
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作者：
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通讯作者：
Carosella, Edgardo D.