Family history of dementia is a risk factor for Lewy body disease
Family history of dementia is a risk factor for Lewy body disease
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DOI：
10.1212/01.wnl.0000219812.20616.b3
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发表时间：
2006-06-27
期刊：
影响因子：
9.9
通讯作者：
Duara, R
中科院分区：
文献类型：
--
作者：
Woodruff, BK;Graff-Radford, NR;Duara, R
遗传因素在阿尔茨海默病(AD)和帕金森病中很重要，但在路易体痴呆(LBD)中还没有很好的特征。作者从AD和LBD的尸检系列中获得了患者的家族史，并在活着的健康对照中进行了研究。与对照组相比，LBD和AD的痴呆症家族史更常见，这表明遗传因素在LBD和AD中同样重要。
Genetic factors are important in Alzheimer disease (AD) and Parkinson disease but have not been well characterized in Lewy body dementia (LBD). The authors obtained family history in patients from an autopsy series of AD and LBD and in living healthy controls. A family history of dementia was more common in both LBD and AD compared with controls, suggesting that genetic factors are as important in LBD as they are in AD.