Dietary intake in adults at risk for Huntington disease Analysis of PHAROS Research Participants
Dietary intake in adults at risk for Huntington disease Analysis of PHAROS Research Participants
复制标题
DOI：
10.1212/wnl.0b013e3181b04aa2
复制
发表时间：
2009-08-01
期刊：
影响因子：
9.9
通讯作者：
Shoulson, I.
中科院分区：
文献类型：
--
作者：
Marder, K.;Zhao, H.;Shoulson, I.
目的：研究前瞻性亨廷顿风险观察研究（PHAROS）参与者的热量摄入、饮食组成和体重指数（BMI）。方法：使用国家癌症研究所食物频率问卷（FFQ）测量652名不符合亨廷顿病临床标准的有亨廷顿病风险的参与者的热量摄入和常量营养素组成。采用Logistic回归检验宏量营养素、BMI、热量摄入和遗传状态（CAG < 37 vs CAG >= 37）之间的关系，并对年龄、性别和教育程度进行调整。采用线性回归确定热量摄入、BMI和CAG重复长度之间的关系。结果：共有435名CAG < 37的参与者和217名CAG >= 37的参与者完成了FFQ。与年龄、性别、教育程度和体重指数调整后的最低四分位数相比，CAG >= 37组的个体在热量摄入的第二、第三或第四个四分位数中有两倍的可能性。这种关系在最高四分位数中减弱，当额外调整总运动评分时。在CAG >= 37的受试者中，较高的热量摄入（而非BMI）与较高的CAG重复长度（校正回归系数= 0.26,p = 0.032）和5年HD发病概率（校正回归系数= 0.024,p = 0.013）相关。校正分析显示各组之间宏量营养素组成没有差异。结论：对于CAG重复长度>= 37的临床未受影响的个体，增加热量摄入可能是维持体重指数的必要条件。这可能与细微运动损伤或高代谢状态引起的能量消耗增加有关。神经病学(R) 2009；73: 385 - 392
Objective: To examine caloric intake, dietary composition, and body mass index (BMI) in participants in the Prospective Huntington At Risk Observational Study (PHAROS).Methods: Caloric intake and macronutrient composition were measured using the National Cancer Institute Food Frequency Questionnaire (FFQ) in 652 participants at risk for Huntington disease (HD) who did not meet clinical criteria for HD. Logistic regression was used to examine the relationship between macronutrients, BMI, caloric intake, and genetic status (CAG < 37 vs CAG >= 37), adjusting for age, gender, and education. Linear regression was used to determine the relationship between caloric intake, BMI, and CAG repeat length.Results: A total of 435 participants with CAG < 37 and 217 with CAG >= 37 completed the FFQ. Individuals in the CAG >= 37 group had a twofold odds of being represented in the second, third, or fourth quartile of caloric intake compared to the lowest quartile adjusted for age, gender, education, and BMI. This relationship was attenuated in the highest quartile when additionally adjusted for total motor score. In subjects with CAG >= 37, higher caloric intake, but not BMI, was associated with both higher CAG repeat length (adjusted regression coefficient = 0.26, p = 0.032) and 5-year probability of onset of HD (adjusted regression coefficient = 0.024; p = 0.013). Adjusted analyses showed no differences in macronutrient composition between groups.Conclusions: Increased caloric intake may be necessary to maintain body mass index in clinically unaffected individuals with CAG repeat length >= 37. This may be related to increased energy expenditure due to subtle motor impairment or a hypermetabolic state. Neurology (R) 2009; 73: 385-392