Gastroesophageal reflux disease increases the risk of chronic rhinosinusitis: a nested case-control study using a national sample cohort
Gastroesophageal reflux disease increases the risk of chronic rhinosinusitis: a nested case-control study using a national sample cohort
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DOI：
10.1002/alr.22259
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发表时间：
2019-04-01
影响因子：
6.4
通讯作者：
Choi, Hyo Geun
中科院分区：
文献类型：
--
作者：
Kim, So Young;Park, Bumjung;Choi, Hyo Geun
背景本研究的目的是评估韩国人群中胃食管反流病 (GERD) 和慢性鼻窦炎 (CRS) 之间的关系。方法从 2002 年至 2013 年对来自韩国国民健康保险服务全国样本队列的受试者（全部 20 岁）进行评估。总共，23,489 名 CRS 参与者与 93,956 名对照者按照 1:4 的比例进行匹配。年龄、群体、性别、收入群体、居住地区、高血压、糖尿病、血脂异常。我们分析了 CRS 组和对照组的既往 GERD 病史。 CRS 组包括使用国际疾病分类第 10 版 (ICD-10) 代码 (J32) 确定的患者，这些患者已接受过 2 次 CRS 治疗并接受了头颈部计算机断层扫描 (CT)。 GERD 组包括使用 ICD-10 (K21) 代码识别的患者，这些患者已治疗 GERD 2 次并服用质子泵抑制剂 (PPI) 2 周。使用非条件逻辑回归分析来分析粗略比值比（OR）和调整比值比（OR）。计算 95% 置信区间 (CI)。根据年龄和性别进行亚组分析。结果 CRS 组的 GERD 发生率（17.1% [23,489 中的 4020]）高于对照组（9.1% [93,956 中的 8522]；p < 0.001）。 CRS 组中 GERD 的调整 OR 为 2.04（95% CI，1.96-2.13；p < 0.001）。亚组分析结果一致。结论 CRS 参与者的 GERD OR 增加。这种关系在所有年龄和性别组中都是一致的。
BackgroundThe purpose of this study was to evaluate the relations between gastroesophageal reflux disease (GERD) and chronic rhinosinusitus (CRS) in a Korean population.MethodsSubjects from the Korean National Health Insurance ServiceNational Sample Cohort, all 20 years old, were assessed from 2002 to 2013. In total, 23,489 CRS participants were matched with 93,956 controls at a ratio of 1:4 with respect to age, group, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed previous history of GERD in the CRS and control groups. The CRS group included patients identified using International Classification of Diseases 10th edition (ICD-10) codes (J32) who had treated their CRS 2 times and had undergone head and neck computed tomography (CT). The GERD group included patients identified using the ICD-10 (K21) code who had treated their GERD 2 times and had taken a proton pump inhibitor (PPI) for 2 weeks. Crude and adjusted odds ratios (ORs) were analyzed using unconditional logistic regression analyses. The 95% confidence intervals (CIs) were calculated. Subgroup analyses were performed according to age and sex.ResultsThe rate of GERD was higher in the CRS group (17.1% [4020 of 23,489]) than in the control group (9.1% [8522 of 93,956]; p < 0.001). The adjusted OR of GERD was 2.04 (95% CI, 1.96-2.13; p < 0.001) in the CRS group. The results of the subgroup analyses were consistent.ConclusionThe ORs of GERD were increased in CRS participants. This relationship was consistent in all age and sex groups.