A functional and structural study of emotion and face processing in children with autism.
A functional and structural study of emotion and face processing in children with autism.
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DOI：
10.1016/j.pscychresns.2008.08.005
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发表时间：
2009-09-30
影响因子：
2.3
通讯作者：
Rivera, Susan M.
中科院分区：
文献类型：
--
作者：
Corbett, Blythe A.;Carmean, Vanessa;Ravizza, Susan;Wendelken, Carter;Henry, Melissa L.;Carter, Cameron;Rivera, Susan M.
自闭症儿童在处理社会情绪信息方面表现出缺陷。杏仁核是社会情感功能的核心结构，与自闭症的神经病理学有关。我们收集了8- 12岁高功能自闭症儿童（n=12）和典型发育儿童（n=15）的结构和功能MRI图像。fMRI实验包括将面部表情和人进行匹配。还进行了杏仁核的体积分析。结果表明，自闭症儿童表现出完整的情绪匹配，但梭状回和杏仁核的激活减弱。相反，自闭症组在一些FG和可变的杏仁核激活中表现出人际匹配的缺陷。左杏仁核和右杏仁核的体积在两组间无显著差异。自闭症儿童的年龄、社交焦虑和杏仁核体积之间存在关联，体积越小，焦虑程度越高，年龄越小。总之，这些数据与老年自闭症患者的研究报告中涉及情绪和面部处理的回路异常一致，显示与情绪处理有关的杏仁核激活减少，与面部处理有关的梭状回激活减少。
Children with autism exhibit impairment in the processing of socioemotional information. The amygdala, a core structure centrally involved in socioemotional functioning, has been implicated in the neuropathology of autism. We collected structural and functional MRI images in children 8-to-12 years of age with high functioning autism (n=12) and typical development (n=15). The fMRI experiment involved matching facial expressions and people. Volumetric analysis of the amygdala was also performed. The results showed that children with autism exhibited intact emotion matching, while showing diminished activation of the fusiform gyrus (FG) and the amygdala. Conversely, the autism group showed deficits in person matching amidst some FG and variable amygdala activation. No significant between group differences in the volume of the left or right amygdala were found. There were associations between age, social anxiety and amygdala volume in the children with autism such that smaller volumes were generally associated with more anxiety and younger age. In summary, the data are consistent with abnormalities in circuits involved in emotion and face processing reported in studies of older subjects with autism showing reductions in amygdala activation related to emotion processing and reduced fusiform activation involved in face processing.
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影响因子：
3.9
作者：
ADRIEN, JL;FAURE, M;SAUVAGE, D
通讯作者：
SAUVAGE, D
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.2
作者：
Adolphs, R;Sears, L;Piven, J
通讯作者：
Piven, J
影响因子：
3.9
作者：
Celani, G;Battacchi, MW;Arcidiacono, L
通讯作者：
Arcidiacono, L
影响因子：
9.9
作者：
Aylward, EH;Minshew, NJ;Pearlson, GD
通讯作者：
Pearlson, GD