Functional Connectivity of the Striatum Links Motivation to Action Control in Humans
Functional Connectivity of the Striatum Links Motivation to Action Control in Humans
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DOI：
10.1523/jneurosci.5415-10.2011
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发表时间：
2011-07-20
影响因子：
5.3
通讯作者：
Ridderinkhof, K. Richard
中科院分区：
文献类型：
--
作者：
Harsay, Helga A.;Cohen, Michael X.;Ridderinkhof, K. Richard
动机提高了有意行为的效率，但这种表现调制如何在人类大脑中实例化仍不清楚。我们使用了一个奖励线索的反跳范式，以调查动机目标（良好的表现奖励的期望）如何调节神经激活和功能连接的模式，以提高反跳性能的准备。从行为上看，当被试知道他们会因为良好的表现而得到奖励时，他们的表现会更好（更快、更准确的反跳）。奖励预期与腹侧和背侧纹状体以及皮质眼区的激活增加有关。尾状核和皮质眼神经控制结构之间的功能连接预测奖励预期的行为益处的个体差异。我们的结论是，虽然背侧和腹侧纹状体电路参与预期的奖励，只有背侧纹状体和其连接的皮质网络参与直接调制的oculabular行为的动机激励。
Motivation improves the efficiency of intentional behavior, but how this performance modulation is instantiated in the human brain remains unclear. We used a reward-cued antisaccade paradigm to investigate how motivational goals (the expectation of a reward for good performance) modulate patterns of neural activation and functional connectivity to improve preparation for antisaccade performance. Behaviorally, subjects performed better (faster and more accurate antisaccades) when they knew they would be rewarded for good performance. Reward anticipation was associated with increased activation in the ventral and dorsal striatum, and cortical oculomotor regions. Functional connectivity between the caudate nucleus and cortical oculomotor control structures predicted individual differences in the behavioral benefit of reward anticipation. We conclude that although both dorsal and ventral striatal circuitry are involved in the anticipation of reward, only the dorsal striatum and its connected cortical network is involved in the direct modulation of oculomotor behavior by motivational incentive.