Stability, precision, and near-24-hour period of the human circadian pacemaker
Stability, precision, and near-24-hour period of the human circadian pacemaker
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DOI：
10.1126/science.284.5423.2177
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发表时间：
1999-06-25
期刊：
影响因子：
56.9
通讯作者：
Kronauer, RE
中科院分区：
文献类型：
--
作者：
Czeisler, CA;Duffy, JF;Kronauer, RE
人类的昼夜节律周期调节被认为与其他物种不同，据报道，活动节律周期为13至65小时（中位数为25.2小时），成年期体温节律周期平均为25小时，并随年龄而缩短。然而，这些观察结果是基于对暴露于足以混淆昼夜节律周期估计的光照水平的人类的研究。生活在精心控制的照明条件下的健康年轻人和老年人的褪黑激素、核心体温和皮质醇的内源性昼夜节律的周期的精确估计现在揭示了人类昼夜节律起搏器的内在周期在两个年龄组中平均为24.18小时，与其他物种的紧密分布一致。这些发现对于理解老年人睡眠中断的病理生理学具有重要意义。
Regulation of circadian period in humans was thought to differ from that of other species, with the period of the activity rhythm reported to range from 13 to 65 hours (median 25.2 hours) and the period of the body temperature rhythm reported to average 25 hours in adulthood, and to shorten with age. However, those observations were based on studies of humans exposed to Light Levels sufficient to confound circadian period estimation. Precise estimation of the periods of the endogenous circadian rhythms of melatonin, core body temperature, and cortisol in healthy young and older individuals Living in carefully controlled Lighting conditions has now revealed that the intrinsic period of the human circadian pacemaker averages 24.18 hours in both age groups, with a tight distribution consistent with other species. These findings have important implications for understanding the pathophysiology of disrupted sleep in older people.