Extrahepatic bile duct atresia and viral involvement
Extrahepatic bile duct atresia and viral involvement
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DOI：
10.1111/j.1399-3046.2005.00257.x
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发表时间：
2005-02-01
影响因子：
1.3
通讯作者：
Nordbo, SA
中科院分区：
文献类型：
--
作者：
Fjær, RB;Bruu, AL;Nordbo, SA
肝外胆道闭锁(EHBA)的发病机制有多种病因：先天性、代谢性、感染性和多因素。在这里，我们提出了一项对10名患有EHBA的儿童的研究，目的是探索病毒感染是他们病情的可能原因。在两年的时间里，所有患有EHBA的婴儿都纳入了一项研究，并在Kasai手术入院时检查了病毒疾病。在10名儿童中的8名和一对父母夫妇中，实验室结果表明最近或持续的病毒感染。巨细胞病毒(CMV)感染4例，EB病毒(EBV)感染5例。2例肝活检组织中检出CMV-DNA，1例肝活检组织中检出EBV-DNA。在10名年龄匹配的对照组中，进行了血清和病毒抗体的聚合酶链反应检测，没有发现病毒感染的迹象。在患有EHBA的婴儿中，CMV或EBV感染的比例出人意料地高，这证明了对这些儿童的病毒疾病进行详尽的检查是合理的。
Several etiological factors have been suggested in the pathogenesis of extrahepatic biliary atresia (EHBA); congenital, metabolic, infectious, and multifactorial. Herein we present a study of 10 children with EHBA, the aim being to explore viral infection as a possible cause of their condition. During a period of 2 yr, all infants with EHBA were included in a study and examined on viral disease on admittance for Kasai operation. In eight of the 10 children and in one parental couple the laboratory results suggested recent or persistent viral infection. Four infections were caused by cytomegalovirus (CMV) and another five by Epstein-Barr virus (EBV). CMV-DNA was detected in two liver biopsies, EBV-DNA in one liver biopsy. In a control group of 10 patients matched by age and tested by PCR in serum and viral antibodies, no sign of viral infections were detected. CMV or EBV infection were present in an unexpectedly high proportion of infants with EHBA, justifying exhaustive examination on viral disease in these children.