Accumulation of Vitamin A in the Hepatic Stellate Cell of Arctic Top Predators
Accumulation of Vitamin A in the Hepatic Stellate Cell of Arctic Top Predators
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DOI：
10.1002/ar.22555
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发表时间：
2012-10-01
影响因子：
2
通讯作者：
Blomhoff, Rune
中科院分区：
文献类型：
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作者：
Senoo, Haruki;Imai, Katsuyuki;Blomhoff, Rune
我们对斯瓦尔巴特群岛和格陵兰岛的哺乳动物和鸟类的肝脏维生素A储存进行了系统的表征。包括北极熊、北极狐、胡海豹和灰鸥在内的顶级捕食者的肝脏含有的维生素A大约是所有其他被研究的北极动物及其基因相关的大陆顶级捕食者肝脏的1020倍。与正常的人类和实验动物如小鼠和大鼠相比，这些值也很高。这种大量的肝脏维生素A位于肝星状细胞(HSCs；也称为维生素A储存细胞、脂肪细胞、间质细胞、脂肪储存细胞或Ito细胞)中的大量自发荧光脂滴中。这些液滴构成了细胞的大部分细胞质。HSCs中这种高效的维生素A储存机制的发展可能有助于顶级捕食者在北极极端环境中的生存。这些动物没有表现出维生素A过多的迹象。我们认为，HSCs具有吸收和储存大量维生素A的能力，这可能在维持食物链、食物链、生物多样性，最终维持北极生态方面发挥关键作用。Anat Rec，2012年。(C)2012年威利期刊公司。
We performed a systematic characterization of the hepatic vitamin A storage in mammals and birds of the Svalbard archipelago and Greenland. The liver of top predators, including polar bear, arctic fox, bearded seal, and glaucous gull, contained about 1020 times more vitamin A than the liver of all other arctic animals studied, as well as their genetically related continental top predators. The values are also high compared to normal human and experimental animals like mouse and rat. This massive amount of hepatic vitamin A was located in large autofluorescent lipid droplets in hepatic stellate cells (HSCs; also called vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells, or Ito cells). The droplets made up most of the cells' cytoplasm. The development of such an efficient vitamin A-storing mechanism in HSCs may have contributed to the survival of top predators in the extreme environment of the arctic. These animals demonstrated no signs of hypervitaminosis A. We suggest that HSCs have capacity to take-up and store large amounts of vitamin A, which may play a pivotal role in maintenance of the food web, food chain, biodiversity, and eventually ecology of the arctic. Anat Rec, 2012. (c) 2012 Wiley Periodicals, Inc.