Risk factors for pre-eclampsia in a large cohort of Latin American and Caribbean women
Risk factors for pre-eclampsia in a large cohort of Latin American and Caribbean women
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DOI：
10.1111/j.1471-0528.2000.tb11582.x
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发表时间：
2000-01-01
期刊：
影响因子：
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通讯作者：
Belizán, JM
中科院分区：
文献类型：
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作者：
Conde-Agudelo, A;Belizán, JM
目的：在一个大的拉丁美洲和加勒比妇女队列中研究先兆子痫的危险因素。设计：回顾性横断面研究，来自围产期信息系统，拉丁美洲围产期学和人类发展中心，乌拉圭蒙得维的亚的数据库。背景：拉丁美洲和加勒比，1985- 1997。人口：700家医院878，680例妊娠;其中42，530例并发先兆子痫，1872例并发子痫。主要结果测量：先兆子痫危险因素的粗和校正相对危险度（RR）。校正后的相对危险度通过基于广义估计方程方法的多元Logistic回归模型校正潜在的混杂因素后获得。（RR 2.38; 95% CI 2.28-2.49）;多胎妊娠（RR 2.10; 95% CI 1.90-2.32）;慢性高血压病史（RR 1.99; 95% CI 1.78-2.22）;妊娠期糖尿病（RR 1.93; 95% CI 1.66-2.25）;母亲年龄≥ 35岁（RR 1.67; 95% CI 1.58-1.77）;胎儿畸形（RR 1.26; 95% CI 1.16-1.37）;母亲不与婴儿的父亲生活在一起（RR 1.21; 95% CI 1.15-1.26）。先兆子痫的风险增加，根据孕前体重指数（BMI）。与孕前BMI正常（19.8 ~ 26.0）的妇女相比，超重妇女（孕前BMI = 26.1 ~ 29.0）和肥胖妇女（孕前BMI > 29.0）的RR估计值分别为1.57（95%CI 1.49-1.64）和2.81（95%CI 2.69-2.94）。妊娠期吸烟和孕前BMI < 19.8是预防先兆子痫发生的重要保护因素。未产妇和多产women.Conclusions的风险因素之间的模式是非常相似的：在拉丁美洲和加勒比地区的妇女观察到的先兆子痫的风险因素是相似的，发现在北美和欧洲的妇女。
Objective: To study risk factors for pre-eclampsia in a large cohort of Latin American and Caribbean women.Design: Retrospective cross-sectional study from the Perinatal Information System, the database of the Latin American Center for Perinatology and Human Development, Montevideo, Uruguay.Setting: Latin America and the Caribbean, 1985-1997.Population: 878,680 pregnancies at 700 hospitals; of these 42,530 were complicated by pre-eclampsia and 1872 by eclampsia.Main outcome measures: Crude and adjusted relative risks (RR) of risk factors for pre-eclampsia. Adjusted relative risks were obtained after adjustment for potential confounding factors through multiple logistic regression models based on the method of generalised estimating equations.Results: The following risk factors were significantly associated with increased risk of pre-eclampsia: nulliparity (RR 2.38; 95% CI 2.28-2.49); multiple pregnancy (RR 2.10; 95% CI 1.90-2.32); history of chronic hypertension (RR 1.99; 95% CI 1.78-2.22); gestational diabetes mellitus (RR 1.93; 95% CI 1.66-2.25); maternal age greater than or equal to 35 years (RR 1.67; 95% CI 1.58-1.77); fetal malformation (RR 1.26; 95% CI 1.16-1.37); and mother not living with infant's father (RR 1.21; 95% CI 1.15-1.26). Preeclampsia risk increased according to pre-pregnancy body mass index (BMI). In comparison with women with a normal pre-pregnancy BMI (19.8 to 26.0), the RR estimates were 1.57 (95% CI 1.49-1.64) and 2.81 95% CI 2.69-2.94), respectively, for overweight women (pre-pregnancy BMI = 26.1 to 29.0) and obese women (pre-pregnancy BMI > 29.0). Cigarette smoking during pregnancy and a pre-pregnancy BMI < 19.8 were significant protective factors against the development of preeclampsia. The pattern of risk factors among nulliparous and multiparous women was quite similar.Conclusions: Risk factors for pre-eclampsia observed among Latin American and Caribbean women are similar to those found among North American and European women.