Short Report: Evaluation of Leishmanin Skin Test in Indian Visceral Leishmaniasis
Short Report: Evaluation of Leishmanin Skin Test in Indian Visceral Leishmaniasis
复制标题
DOI：
10.4269/ajtmh.2009.80.566
复制
发表时间：
2009-04-01
影响因子：
3.3
通讯作者：
Sundar, Shyam
中科院分区：
文献类型：
--
作者：
Gidwani, Kamlesh;Rai, Madhukar;Sundar, Shyam
我们评估了50例内脏利什曼病（VL）患者，124例治愈VL患者在不同的时间间隔，125名健康对照从流行区（HEC），和14名健康对照从非流行区（NEHC）的利什曼菌素皮肤试验（LST）的性能。所用的利什曼菌素抗原基于硕大利什曼原虫，并从巴斯德研究所（伊朗）获得。活动性VL患者LST阳性率为14.0%，治愈患者为40.3%，HEC为21.6%，NEHC为0%。活动性VL患者中14%的阳性率与普遍认为此类患者因无反应性而应为阴性的观点相冲突。此外，在治愈的VL患者中观察到LST缺乏敏感性。由L.来自印度的donovani菌株应加以研究。
We evaluated the performance of the leishmanin skin test (LST) in 50 patients with visceral leishmaniasis (VL), 124 cured VL patients at different time intervals, 125 healthy controls from an endemic region (HEC), and 14 healthy controls from a non-endemic region (NEHC). The leishmanin antigen used was based on Leishmania major and was obtained from the Pasteur Institute (Iran). A positive LST was found in 14.0% of patients with active VL, 40.3% of cured patients, 21.6% of HECs, and 0% in NEHCs. The 14% positivity in patients with active VL conflicts with the widely held opinion that such patients should be negative because of anergy. Also, a lack of sensitivity of the LST was observed in cured VL patients. An LST antigen produced from L. donovani strains from India should be explored.