Models of the cardiac L-type calcium current: A quantitative review.
Models of the cardiac L-type calcium current: A quantitative review.
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DOI：
10.1002/wsbm.1581
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发表时间：
2023-01
影响因子：
3.1
通讯作者：
中科院分区：
文献类型：
--
作者：
L型钙电流（）在心脏电生理学中起着关键作用，模型是预测药物和突变致心律失常性的重要工具。五十年的测量和建模已经产生了几个相互竞争的理论（编码在数学方程中）。然而，新模型的引入通常不会伴随着与以前工作的数据驱动的关键比较，因此不清楚哪种模型最适合任何特定的应用。在这篇综述中，我们描述和比较了73种已发表的哺乳动物模型，并使用模拟实验来表明，它们的预测存在很大的变异性，当按物种或其他类别分组时，这种变异性并没有明显减弱。我们提供了60个模型的模型代码，列出了主要的数据源，并讨论了减少这一庞大的竞争理论列表所需的实验和建模工作，并最终开发出一个社区共识模型。心血管疾病>计算模型心血管疾病>分子和细胞生理学本文分类如下：我们讨论了73种已发表的哺乳动物ICaL模型，并发现门控动力学、电化学驱动力和对内部钙浓度的敏感性存在差异，导致其预测存在相当大的差异。
The L‐type calcium current () plays a critical role in cardiac electrophysiology, and models of are vital tools to predict arrhythmogenicity of drugs and mutations. Five decades of measuring and modeling have resulted in several competing theories (encoded in mathematical equations). However, the introduction of new models has not typically been accompanied by a data‐driven critical comparison with previous work, so that it is unclear which model is best suited for any particular application. In this review, we describe and compare 73 published mammalian models and use simulated experiments to show that there is a large variability in their predictions, which is not substantially diminished when grouping by species or other categories. We provide model code for 60 models, list major data sources, and discuss experimental and modeling work that will be required to reduce this huge list of competing theories and ultimately develop a community consensus model of . Cardiovascular Diseases > Computational Models Cardiovascular Diseases > Molecular and Cellular Physiology This article is categorized under: We discuss 73 published models of mammalian ICaL and find differences in gating kinetics, electrochemical driving force, and sensitivity to internal calcium concentrations, leading to considerable variability in their predictions.
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影响因子：
5.6
作者：
Bers DM;Morotti S
通讯作者：
Morotti S
影响因子：
3.4
作者：
Silva JR
通讯作者：
Silva JR
影响因子：
4.5
作者：
CAVALIE, A;PELZER, D;TRAUTWEIN, W
通讯作者：
TRAUTWEIN, W
影响因子：
5.5
作者：
BEELER, GW;REUTER, H
通讯作者：
REUTER, H
DOI：
10.1113/jp275733
发表时间：
2018-05-15
期刊：
The Journal of physiology
影响因子：
--
作者：
Beattie KA;Hill AP;Bardenet R;Cui Y;Vandenberg JI;Gavaghan DJ;de Boer TP;Mirams GR
通讯作者：
Mirams GR