Diurnal levels of Fos immunoreactivity are elevated within hypocretin neurons in lactating mice
Diurnal levels of Fos immunoreactivity are elevated within hypocretin neurons in lactating mice
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DOI：
10.1016/j.peptides.2004.06.006
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发表时间：
2004-11-01
期刊：
影响因子：
3
通讯作者：
Gammie, SC
中科院分区：
文献类型：
--
作者：
España, RA;Berridge, CW;Gammie, SC
下丘脑分泌素通过多个终端场的作用来调节觉醒。因此，下丘脑泌素神经传递的改变可能导致哺乳期间观察到的睡眠模式改变。本研究探讨了哺乳是否与雌性小鼠下丘脑分泌素神经元数量的改变和下丘脑分泌素神经元内的昼夜fos免疫反应性有关。在两个下丘脑分泌素末端区域也检测了fos免疫反应性的改变；内侧视前区和蓝斑。哺乳期雌鼠下丘脑分泌素神经元和内侧视前区fos免疫反应性增强。在蓝斑内的下丘脑分泌素神经元数量和fos免疫反应性方面没有观察到差异。(C) 2004爱思唯尔公司版权所有。
The hypocretins modulate arousal via actions across multiple terminal fields. Thus, alterations in hypocretin neurotransmission may contribute to altered sleep patterns observed during lactation. This study examined whether lactation is associated with alterations in the number of hypocretin neurons and in diurnal Fos-immunoreactivity within hypocretin neurons in female mice. Alterations in Fos-immunoreactivity were also examined within two hypocretin terminal regions; the medial preoptic area and the locus coeruleus. Fos-immunoreactivity was increased within hypocretin neurons and the medial preoptic area in lactating females. No differences were observed in the number of hypocretin neurons or in Fos-immunoreactivity within the locus coeruleus. (C) 2004 Elsevier Inc. All rights reserved.