Interactions between sleep disturbances and Alzheimer's disease on brain function: a preliminary study combining the static and dynamic functional MRI
Interactions between sleep disturbances and Alzheimer's disease on brain function: a preliminary study combining the static and dynamic functional MRI
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DOI：
10.1038/s41598-019-55452-9
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发表时间：
2019-12-13
影响因子：
4.6
通讯作者：
Zhang, Minming
中科院分区：
文献类型：
--
作者：
Li, Kaicheng;Luo, Xiao;Zhang, Minming
尽管睡眠障碍是阿尔茨海默病（AD）的危险因素，但其潜在机制仍不清楚。本研究旨在探讨睡眠障碍和 AD 对大脑功能的相互作用。我们纳入了 192 名正常对照、111 名轻度认知障碍 (MCI) 和 30 名 AD 患者，睡眠质量较差或正常（分别为 PS、NS）。为了探索大脑活动的强度和稳定性，我们使用低频波动的静态幅度（sALFF）和动态 ALFF（dALFF）方差。此外，我们检查了白质高信号 (WM H) 和淀粉样蛋白 PET 沉积，分别代表血管危险因素和 AD 相关标志。我们观察到睡眠障碍与疾病严重程度显着相互作用，揭示了对 sALFF 和 dALFF 方差的明显影响。有趣的是，PS 组的 dALFF 方差轨迹沿着 AD 谱先增加，然后减少，最后增加，而 sALFF 则显示相反的轨迹。进一步的相关分析表明，PS 组中 WM H 负担与 dALFF 方差相关。总之，我们的研究表明，睡眠障碍与 AD 严重程度存在相互作用，分别表现为 MCI 的代偿效应和 AD 的失代偿效应。此外，血管损伤可能是睡眠与 AD 之间相互作用的重要发病机制。
Though sleep disturbance constitutes the risk factor for Alzheimer's disease (AD), the underlying mechanism is still unclear. This study aims to explore the interaction between sleep disturbances and AD on brain function. We included 192 normal controls, 111 mild cognitive impairment (MCI), and 30 AD patients, with either poor or normal sleep (PS, NS, respectively). To explore the strength and stability of brain activity, we used static amplitude of low-frequency fluctuation (sALFF) and dynamic ALFF (dALFF) variance. Further, we examined white matter hyperintensities (WM H) and amyloid PET deposition, representing the vascular risk factor and AD-related hallmark, respectively. We observed that sleep disturbance significantly interacted with disease severity, exposing distinct effects on sALFF and dALFF variance. Interestingly, PS groups showed the dALFF variance trajectory of initially increased, then decreased and finally increased along the AD spectrum, while showing the opposite trajectory of sALFF. Further correlation analysis showed that the WM H burden correlates with dALFF variance in PS groups. Conclusively, our study suggested that sleep disturbance interacts with AD severity, expressing as effects of compensatory in MCI and de-compensatory in AD, respectively. Further, vascular impairment might act as important pathogenesis underlying the interaction effect between sleep and AD.