Effects of structural property and surface modification of Ti6Ta4Sn scaffolds on the response of SaOS2 cells for bone tissue engineering
Effects of structural property and surface modification of Ti6Ta4Sn scaffolds on the response of SaOS2 cells for bone tissue engineering
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DOI：
10.1016/j.jallcom.2010.01.026
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发表时间：
2010-04-02
影响因子：
6.2
通讯作者：
Wen, Cui'e
中科院分区：
文献类型：
--
作者：
Li, Yuncang;Xiong, Jianyu;Wen, Cui'e
研究了新型多孔Ti6 Ta 4Sn合金支架的物理性能，包括孔隙率和孔径以及各种表面改性，以观察其对成骨样SaOS（2）细胞的影响。结果表明，细胞在支架上的粘附密度在25- 75%的范围内与孔隙率成正比，但在75-900 μ m的范围内与孔径成反比。碱热处理（AH）、溶胶-凝胶羟基磷灰石涂层（HA）和碱热处理加模拟体液（SBF）浸泡等表面改性处理均能显著增强成骨样细胞在Ti6 Ta 4Sn支架上的粘附。还注意到，溶胶-凝胶羟基磷灰石涂层工艺在增强支架的细胞粘附密度方面比其他两种工艺（AH和AH + SBF浸泡）更有效。多孔Ti6 Ta 4Sn支架具有良好的生物力学性能、体外生物活性和生物相容性，是一种很有前途的骨科植入材料。(C)2010 Elsevier B. V.保留所有权利。
The physical properties of the new porous Ti6Ta4Sn alloy scaffold, including the porosity and the pore size and various surface modifications, were investigated in terms of its effect on osteoblast-like SaOS(2) cells. Results indicated that the cell adhesion density on the scaffolds was directly proportional to porosity in the range of 25-75%, but was inversely proportional to pore size in the range of 75-900 mu m. Surface modifications, including alkali-heat treatment (AH), sol-gel hydroxyapatite coating (HA) and alkali-heat treatment plus simulated body fluid (SBF) soaking, significantly enhanced the osteoblast-like cell adhesion on the Ti6Ta4Sn scaffold. It is also noticed that the sol-gel hydroxyapatite coating process was more effective compared to the other two processes (AH and AH plus SBF soaking) in terms of enhancing the cell adhesion density of the scaffold. The porous Ti6Ta4Sn scaffold is thought to be a promising orthopedic implant material by virtue of its excellent biomechanical properties, in vitro bioactivity and biocompatibility highly preferred by osteoblast-like cells. (C) 2010 Elsevier B.V. All rights reserved.