Fundamental subchondral bone changes in spontaneous knee osteoarthritis
Fundamental subchondral bone changes in spontaneous knee osteoarthritis
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DOI：
10.1016/j.biocel.2004.06.016
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发表时间：
2005-01-01
影响因子：
4
通讯作者：
Bailey, AJ
中科院分区：
文献类型：
--
作者：
Anderson-MacKenzie, JM;Quasnichka, HL;Bailey, AJ
骨关节炎具有未知的病因，并且不能可靠地获得来自早期人类骨关节炎组织的组织样品。因此，理解OA的发展依赖于使用动物模型：例如Dunkin-Hartley豚鼠品系中观察到的自发变化，其在生物化学、组织学和放射学上与人类OA相似。我们研究骨变化的作用，在早期骨关节炎的发展，使用非骨关节炎发展布里斯托株-2作为对照，从3至36周的标准微焦点X射线成像和组织学技术。髌骨，胫骨和股骨骨骺区和直接的软骨下区的骨密度在所有年龄analsed，我们发现，无论是放射学和组织学骨关节炎评分递增的Dunkin-Hartley，但不是为BS 2证明其价值作为对照。Dunkin-Hartley有较高的骨密度和更大的软骨下骨厚度从24周龄。我们得出结论，之前的任何严重的骨关节炎病理的Dunkin-Hartley正在进行软骨下骨重塑，从而证明了骨关节炎的发展中的早期骨重塑的基本作用。(C)2004爱思唯尔有限公司保留所有权利。
Osteoarthritis has an unknown aetiology, and tissue samples from early stage human osteoarthritis tissue cannot be reliably obtained. Therefore understanding the development of OA relies on using animal models: such as the spontaneous changes seen in the Dunkin-Hartley guinea pig strain, which are biochemically, histologically and radiologically similar to human OA. We investigated the role of bone change in early OA development using the non-OA developing Bristol strain-2 as control from 3 to 36 weeks by standard microfocal X-ray imaging and histological techniques. The patella, tibia and femur epiphyseal region and immediate subchondral area were anal sed for bone density at all ages.We found that both radiological and histological osteoarthritis scores increased progressively for the Dunkin-Hartley, but not for the BS2 demonstrating its value as a control. The Dunkin-Hartley had a higher bone density and greater subchondral bone thickness from 24 weeks of age.We conclude that prior to any gross osteoarthritis pathology the Dunkin-Hartley are undergoing subchondral bone remodelling, thus demonstrating the fundamental role of early bone remodelling in the development of osteoarthritis. (C) 2004 Elsevier Ltd. All rights reserved.