Annals of Clinical Microbiology and Antimicrobials Open Access Evaluating Antibiotics for Use in Medicine Using a Poloxamer Biofilm Model
Annals of Clinical Microbiology and Antimicrobials Open Access Evaluating Antibiotics for Use in Medicine Using a Poloxamer Biofilm Model
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临床微生物学和抗菌药物年鉴开放获取使用泊洛沙姆生物膜模型评估抗生素在医学中的使用
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通讯作者：
Percival
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作者：
A. Clutterbuck;C. Cochrane;J. Dolman;S. Percival;Jayne Uk;J. Dolman;Steven L Com;Percival
背景：伤口感染，由于生物膜，是一个经常性的问题，因为他们对抗生素的排斥性。选择适当的抗生素治疗这些生物膜感染是很重要的。用于抗生素选择的传统体外圆盘扩散法使用在琼脂平板上生长的细菌培养物。然而，琼脂上的细菌生长形式并不能代表细菌在伤口和其他组织部位中的生长方式，因为这里的细菌在生物膜中自然生长。本研究的目的是测试一种更合适的方法来测试生物膜上的抗菌效力，并与用于抗生素敏感性测试的标准方法进行比较。
Background: Wound infections, due to biofilms, are a constant problem because of their recalcitrant nature towards antibiotics. Appropriate antibiotic selection for the treatment of these biofilm infections is important. The traditional in vitro disc diffusion method for antibiotic selection uses bacterial cultures grown on agar plates. However, the form of bacterial growth on agar is not representative of how bacteria grow in wounds and other tissue sites as here bacteria grow naturally in a biofilm. The aim of this research was to test a more appropriate method for testing antimicrobial efficacy on biofilms and compare with the standard methods used for antibiotic sensitivity testing.