Histopathology of Non-Alcoholic Fatty Liver Disease
Histopathology of Non-Alcoholic Fatty Liver Disease
复制标题
DOI：
10.1016/j.cld.2009.07.008
复制
发表时间：
2009-11-01
影响因子：
5.1
通讯作者：
Brunt, Elizabeth M.
中科院分区：
文献类型：
--
作者：
Brunt, Elizabeth M.
目前的成像方法可以以越来越高的准确性检测脂肪变性，但不能检测炎症或肝实质的炎前纤维化或重塑。影像学也不能评估肝脂肪变性的类型或定位。随着越来越多地使用啮齿动物研究NAFLD/NASH，仔细分析或阅读强调了以下事实：尽管研究者使用了类似的术语，但在许多流行的NAFLD/NASH动物模型中报告的肝组织评价通常不能模拟人类疾病的许多重要方面。本综述将集中在人类疾病的研究结果。
Current imaging methodologies can detect steatosis with increasing accuracy but cannot detect inflammation or pre-cirrhotic fibrosis or remodeling of the liver parenchyma. Imaging also cannot assess types or localization of hepatic steatosis. With the increased use of rodents to study NAFLD/NASH, careful analysis or reading highlights the fact that liver tissue evaluations reported in many of the popular animal models of NAFLD/NASH often do not imitate many of the significant aspects of the human disease, despite similar terminology applied by investigators. This review will focus on the findings in human disease.