Corticostriatal Connectivity Underlies Individual Differences in the Balance between Habitual and Goal-Directed Action Control
Corticostriatal Connectivity Underlies Individual Differences in the Balance between Habitual and Goal-Directed Action Control
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DOI：
10.1523/jneurosci.1088-12.2012
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发表时间：
2012-08-29
影响因子：
5.3
通讯作者：
Ridderinkhof, K. Richard
中科院分区：
文献类型：
--
作者：
de Wit, Sanne;Watson, Poppy;Ridderinkhof, K. Richard
为什么有些人比其他人更容易养成僵化的习惯？在目前的研究中，我们使用扩散张量成像来证明，大脑的连通性预测了人类在相对目标导向和习惯性行为控制方面的个体差异。具体地说，通过估计从后壳核播种的运动前皮质中的白质束强度(以及通过基于体素的形态计量学确定的后壳核中的灰质密度)，可以预测习惯性的行动失误对不再有回报的结果的易感性。相反，通过估计尾状核播种的腹内侧额叶皮质的束强度，可以预测灵活的目标导向行动。这些发现表明，在健康人群中，可分离的皮质纹状体通路的完整性是行为控制的个体差异的基础，这可能最终调节对冲动控制障碍的易感性。
Why are some individuals more susceptible to the formation of inflexible habits than others? In the present study, we used diffusion tensor imaging to demonstrate that brain connectivity predicts individual differences in relative goal-directed and habitual behavioral control in humans. Specifically, vulnerability to habitual "slips of action" toward no-longer-rewarding outcomes was predicted by estimated white matter tract strength in the premotor cortex seeded from the posterior putamen (as well as by gray matter density in the posterior putamen as determined with voxel-based morphometry). In contrast, flexible goal-directed action was predicted by estimated tract strength in the ventromedial prefrontal cortex seeded from the caudate. These findings suggest that integrity of dissociable corticostriatal pathways underlies individual differences in action control in the healthy population, which may ultimately mediate vulnerability to impulse control disorders.