Results of carbon ion radiotherapy in 152 patients
Results of carbon ion radiotherapy in 152 patients
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DOI：
10.1016/j.ijrobp.2003.09.041
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发表时间：
2004-02-01
影响因子：
7
通讯作者：
Debus, J
中科院分区：
文献类型：
--
作者：
Schulz-Ertner, D;Nikoghosyan, A;Debus, J
目的：本研究总结了1997年以来德国达姆施塔特（Darmstadt） schellschaft fur Schwerionenforschung （GSI）光栅扫描碳离子放射治疗（RT）的经验。方法与材料：1997年12月至2002年12月，对152例颅底脊索瘤和低级别软骨肉瘤患者行碳离子放射治疗，其中87例单纯接受碳离子放射治疗，中位剂量60 GyE；对21例不良腺样囊性癌患者和17例脊柱脊索瘤和软骨肉瘤患者（n = 9）、骶尾骨脊索瘤和软骨肉瘤患者（n = 8）进行光子和碳离子联合放疗。12例复发肿瘤患者接受碳离子再照射，同时或不进行光子放疗。此外，15例颅底肿瘤患者除脊索瘤和低级别软骨肉瘤外，均采用碳离子治疗。结果：精算3年局部控制率脊索瘤为81%，软骨肉瘤为100%，腺样囊性癌为62%。15/17例脊柱脊索瘤或软骨肉瘤患者（8/9）和骶部脊索瘤或软骨肉瘤患者（7/8）以及11/15例颅底肿瘤非脊索瘤和低级别软骨肉瘤患者分别获得局部对照。12名接受再照射的患者中有6名仍然存活，没有肿瘤进展的迹象。未观察到4级或5级毒性。结论：碳离子治疗对脊索瘤、低级别软骨肉瘤和不利的腺样囊性癌等颅底肿瘤具有较高的局部控制率和安全性。(C) 2004爱思唯尔公司
Purpose: This study summarizes the experience with raster scanned carbon ion radiation therapy (RT) at the Gesellschaft fur Schwerionenforschung (GSI), Darmstadt, Germany since 1997.Methods and Materials: Between December 1997 and December 2002, 152 patients were treated at GSI with carbon ion RT. Eighty-seven patients with chordomas and low-grade chondrosarcomas of the skull base received carbon ion RT alone (median dose 60 GyE); 21 patients with unfavorable adenoid cystic carcinomas and 17 patients with spinal (n = 9) and sacrococcygeal (n = 8) chordomas and chondrosarcomas were treated with combined photon and carbon ion RT. Twelve patients received reirradiation with carbon ions with or without photon RT for recurrent tumors. Furthermore, 15 patients with skull base tumors other than chordoma and low-grade chondrosarcoma were treated with carbon ions.Results: Actuarial 3-year local control was 81% for chordomas, 100% for chondrosarcomas, and 62% for adenoid cystic carcinomas. Local control was obtained in 15/17 patients with spinal (8/9) and sacral (7/8) chordomas or chondrosarcomas and in 11/15 patients with skull base tumors other than chordomas and low-grade chondrosarcomas, respectively. Six of 12 patients who received reirradiation are still alive without signs of tumor progression. Common Toxicity Criteria Grade 4 or Grade 5 toxicity was not observed.Conclusion: Carbon ion therapy is safe with respect to toxicity and offers high local control rates for skull base tumors such as chordomas, low-grade chondrosarcomas, and unfavorable adenoid cystic carcinomas. (C) 2004 Elsevier Inc.