Sex differences in medial and lateral orbitofrontal cortex hypoperfusion in cocaine-dependent men and women.
Sex differences in medial and lateral orbitofrontal cortex hypoperfusion in cocaine-dependent men and women.
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DOI：
10.1016/s1550-8579(06)80209-3
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发表时间：
2006-09-01
期刊：
影响因子：
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通讯作者：
Devous, Michael D Sr
中科院分区：
文献类型：
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作者：
Adinoff, Bryon;Williams, Mark J;Devous, Michael D Sr
背景：可卡因依赖男性和女性的不同临床轨迹可能是不同神经生物学基础的结果。此前曾报道可卡因成瘾者存在眶额皮质 (OFC) 灌注不足的情况，并被认为是由于冲动或决策受损而导致复发的生物介质。 目的：本研究评估了戒除可卡因依赖的男性和女性与性别匹配的健康对照之间的区域脑血流量 (rCBF)。 方法：可卡因依赖受试者戒除可卡因 11 至 28 天并且没有其他严重的心理健康或药物滥用障碍。在注射安慰剂盐水后，通过单光子发射计算机断层扫描评估 rCBF。还对可卡因依赖者和对照男性的子集进行了静息扫描。 结果：在接受检查的 35 名可卡因依赖者和 37 名健康对照者中，观察到左侧 (P=0.001)、右侧 (P=0.002) 和内侧 (P
BACKGROUND: The different clinical trajectories of cocaine-dependent men and women may be a consequence of distinct neurobiological substrates. Hypoperfusion of the orbitofrontal cortex (OFC) has previously been reported in individuals addicted to cocaine and has been posited as a biological mediator of relapse due to impulsivity or impaired decision making.OBJECTIVE: This study assessed regional cerebral blood flow (rCBF) between abstinent cocaine-dependent men and women and sex-matched healthy controls.METHODS: Cocaine-dependent subjects were abstinent from cocaine for 11 to 28 days and had no other major mental health or substance use disorders. rCBF was assessed with single photon emission computed tomography after administration of a placebo saline infusion. A resting scan was also obtained in a subset of cocaine-dependent and control men.RESULTS: In the 35 cocaine-dependent and 37 healthy control subjects examined, a sex-by-group effect was observed for the left lateral (P=0.001), right lateral (P=0.002), and medial (P