An event-related potential study on exposure therapy for patients suffering from spider phobia
An event-related potential study on exposure therapy for patients suffering from spider phobia
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DOI：
10.1016/j.biopsycho.2009.09.003
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发表时间：
2009-12-01
影响因子：
2.6
通讯作者：
Schienle, Anne
中科院分区：
文献类型：
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作者：
Leutgeb, Verena;Schaefer, Axel;Schienle, Anne
本研究探讨了蜘蛛恐惧症雌性动物接受认知行为疗法(CBT)后的大脑皮层变化。在第一次脑电检查中，45名患者和20名非恐惧症女性被展示了与恐惧症相关的、通常引起恐惧、引起厌恶和情感中立的图片。恐惧症患者被随机分配到治疗组(TG)或等待名单组(WG)。在CBT后或等待一段时间后重复脑电测量。分别在340~500ms(P300)、550~770ms(LPP，早期LPP)和800~1500ms(LPP晚期)时间窗提取事件相关电位。与对照组相比，未经治疗的恐惧症患者对蜘蛛图片的反应显示出P300和早期LPP的幅度增加。这很可能反映了恐惧症刺激的情感意义，它会自动吸引注意力。治疗效果包括对蜘蛛图片的晚期LPP波幅显著增强。结果从减少注意回避的角度进行了讨论。(C)2009爱思唯尔B.V.保留所有权利。
The present event-related potential (ERP) study investigated electrocortical changes related to cognitive behavior therapy (CBT) in spider phobic females. Forty-five patients and twenty non-phobic women were presented with phobia-relevant, generally fear-inducing, disgust-inducing and affectively neutral pictures in a first EEG session. Phobic patients were randomly assigned to either a therapy (TG) or a waiting-list (WG) group. EEG measurement was repeated after CBT or a waiting period. ERPs were extracted in the time windows 340-500 ms (P300), 550-770 ms (late positive potential (LPP), early LPP) and 800-1500 ms (late LPP). Relative to controls, untreated phobics showed enhanced amplitudes of P300 and early LPP in response to spider pictures. This most likely reflects the emotional significance of the phobic stimulus, which automatically draws attention. The therapy effect consisted of a significant enhancement of late LPP amplitudes in response to spider pictures. Results are discussed in terms of reduced attentional avoidance. (C) 2009 Elsevier B.V. All rights reserved.