Optically Active 2,3-Allenoates via Palladium-Catalyzed Carbonylation of Enantioenriched Propargylic Mesylates
Optically Active 2,3-Allenoates via Palladium-Catalyzed Carbonylation of Enantioenriched Propargylic Mesylates
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通过对映体富集的丙炔甲磺酸酯的钯催化羰基化得到光学活性 2,3-联烯酸酯
DOI：
10.1002/adsc.201200910
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发表时间：
2013
影响因子：
5.4
通讯作者：
Shengming Ma
中科院分区：
文献类型：
--
作者：
Yuli Wang;Shengming Ma
在温和的条件下，以(S)‐（−）‐5,5′‐双（二苯基膦）- 4,4′‐双- 1,3‐苯二氮唑[(S)‐SEGPHOS] （3 mol%）为催化剂，以磷酸氢二铵（1.1等量）为碱，以(S)‐二苯基膦]（3 mol%）为催化剂，以(S)‐二苯基膦]（3 mol%）为底物，由对映体富集的丙炔甲磺酸为原料合成了具有光学活性的2,3‐丙烯酸酯，收率中至优异，手性转移效率高。
Under mild conditions, optically active 2,3‐allenoates were synthesized from enantioenriched propargylic mesylates with moderate to excellent yields and high efficiency of chirality transfer by using palladium(0) bis(dibenzylideneacetone) (3 mol%) with (S)‐(−)‐5,5′‐bis(diphenylphosphino)‐4,4′‐bi‐1,3‐benzodioxole [(S)‐SEGPHOS] (3 mol%) as the catalyst and diammonium hydrogen phosphate (1.1 equiv .) as the base.