Comparison of Oral Glucose Loading and Intravenous Glucagon Injection as Stimuli to C‐peptide Secretion in Normal Men
Comparison of Oral Glucose Loading and Intravenous Glucagon Injection as Stimuli to C‐peptide Secretion in Normal Men
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口服葡萄糖负荷与静脉注射胰高血糖素刺激正常男性 C 肽分泌的比较
DOI：
10.1111/j.1464-5491.1985.tb00630.x
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发表时间：
1985
影响因子：
3.5
通讯作者：
A. Maccuish
中科院分区：
文献类型：
--
作者：
M. Small;H. Cohen;Beastall Gh;A. Maccuish
在10名健康男性中，我们比较了静脉注射胰高血糖素（1 mg）和口服葡萄糖负荷（75 G）在诱发胰腺释放C肽和胰岛素方面的各自作用。血清C肽和胰岛素浓度在胰高血糖素注射后6分钟分别升高至中位值190%和500%，在葡萄糖摄入后30分钟分别升高至344%和794%，在60分钟分别升高至268%和278%。在测试β细胞功能方面，口服葡萄糖负荷与胰高血糖素注射一样有效，并且没有通常与胰高血糖素相关的令人不快的副作用（恶心、呕吐、晕厥）。我们得出结论，口服葡萄糖负荷可能是筛选正常受试者β细胞功能是否充足时引发C肽释放的首选试验。
In 10 healthy men, we have compared the respective effects of an intravenous injection of glucagon (1 mg) and an oral glucose load (75 G) in eliciting the release of C‐peptide and insulin from the pancreas. Serum C‐peptide and insulin concentrations increased respectively to median values of 190% and 500% at 6 minutes after glucagon injection, and to 344% and 794% at 30 minutes and 268% and 278% at 60 minutes following glucose ingestion. The oral glucose load was as effective as glucagon injection in testing beta cell function and was free from the unpleasant side effects (nausea, vomiting, syncope) commonly associated with glucagon. We conclude that oral glucose loading is probably the test of choice to elicit C‐peptide release when screening populations of normal subjects for adequacy of beta cell function.