Presentation of Seasonal Influenza A in Pregnancy 2003-2004 Influenza Season
Presentation of Seasonal Influenza A in Pregnancy 2003-2004 Influenza Season
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DOI：
10.1097/aog.0b013e3181da0c5e
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发表时间：
2010-05-01
影响因子：
7.2
通讯作者：
Wendel, George D., Jr.
中科院分区：
文献类型：
--
作者：
Rogers, Vanessa Laibl;Sheffield, Jeanne S.;Wendel, George D., Jr.
目的：描述流感的临床过程中，孕妇在我们的机构在2003-2004年流感season.METHODS：这是一个前瞻性的评价，所有孕妇诊断为甲型流感2003年10月22日，2004年1月18日。使用快速诊断测试、培养或两者兼而有之来评估出现流感样疾病的孕妇。患者根据前瞻性制定的临床方案入院。经实验室确诊的妇女接受疾病控制中心推荐的抗病毒药物治疗。结果：107例患者确诊为甲型流感。获得的所有病毒分离株均为H3 N2毒株。流感最常见于妊娠晚期（45%）。咳嗽是最常见的症状（93%），其次是肌痛（61%），恶心或呕吐（60%）和溢液（56%）。84%的女性没有合并症;然而，62%的女性需要入院。21%的患者的最大心率高于每分钟130次。甲型流感的并发症包括肺炎（12%）、脑膜炎（1%）和心肌炎（1%）。没有产妇死亡。81名（76%）妇女在我们机构分娩。当与我们的一般产科人口相比，产科或新生儿并发症没有显着差异。结论：甲型流感在妊娠期的特点是咳嗽，肌痛，恶心或呕吐，和溢液。严重的心动过速不成比例的产妇发热独特的影响大多数妇女在我们的队列。肺炎并发症八分之一的情况下，然而，预期的额外产妇发病率和死亡率并没有发生。（妇产科2010;115：924-9）
OBJECTIVE: To describe the clinical course of influenza in pregnant women followed at our institution during the 2003-2004 influenza season.METHODS: This was a prospective evaluation of all pregnant women diagnosed with influenza A between October 22, 2003, and January 18, 2004. Pregnant women presenting with a flu-like illness were evaluated using a rapid diagnostic test, culture, or both. Patients were admitted in accordance with prospectively developed clinical protocols. Women with a laboratory-confirmed diagnosis were treated with Centers for Disease Control-recommended antivirals.RESULTS: Influenza A was confirmed in 107 patients. All viral isolates obtained were of the H3N2 strain. Influenza was most commonly diagnosed in the third trimester (45%). Cough was the most commonly reported symptom (93%), followed by myalgias (61%), nausea or vomiting (60%), and rhinorrhea (56%). Eighty-four percent of the women had no comorbid conditions; however, 62% required admission. Twenty-one percent of patients had a maximum heart rate higher than 130 beats per minute. Complications of influenza A included pneumonia (12%), meningitis (1%), and myocarditis (1%). There were no maternal deaths. Eighty-one (76%) of the women delivered at our institution. When compared with our general obstetric population, there was no significant difference in obstetric or neonatal complications.CONCLUSION: Influenza A in pregnancy is characterized by cough, myalgia, nausea or vomiting, and rhinorrhea. Profound tachycardia disproportionate to maternal fever uniquely affected the majority of the women in our cohort. Pneumonia complicated one in eight cases; however, the anticipated excess maternal morbidities and mortality did not occur. (Obstet Gynecol 2010;115:924-9)