GROWTH ALLOMETRY OF THE ORGANS IN GIANT TRANSGENIC MICE
GROWTH ALLOMETRY OF THE ORGANS IN GIANT TRANSGENIC MICE
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DOI：
10.1210/endo-121-6-1924
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发表时间：
1987-12-01
期刊：
影响因子：
4.8
通讯作者：
BRINSTER, RL
中科院分区：
文献类型：
--
作者：
SHEA, BT;HAMMER, RE;BRINSTER, RL
我们分析了巨型转基因 (MTrGH) 和同窝对照小鼠一系列内脏器官的绝对和相对（异速）生长，以确定激素环境改变对这些啮齿类动物生长的一般和器官特异性影响。两个样本之间器官重量和外部身体尺寸的横截面生长异速性的比较基于协方差分析。我们报告说，除大脑外，所有检查的器官和测量结果的生长均显着增加。在许多情况下，异速生长系数与等长值显着不同，因此，成年转基因小鼠表现出与成年对照不同的身体比例。大多数这些形状差异反映了一般异速尺寸的增加，但转基因的肝脏和脾脏经历了特殊的扩大或生长。这些结果表明，GH 和 IGF-I 水平升高的主要影响是总体生长加快，但相对比例由各个器官和身体区域的内在控制决定。
We have analyzed the absolute and relative (allometric) growth of a series of internal organs in giant transgenic (MTrGH) and littermate control mice to determine the general and organ-specific effects of the altered hormonal environment on growth in these rodents. Comparison of cross-sectional growth allometries of organ weights and external body dimensions between the two samples was based on analyses of covariance. We report significantly increased growth in all of the organs and measurements examined except for the brain. Coefficients of growth allometry differ significantly from isometric values in a number of cases, and thus, the adult transgenic mice exhibit body proportions different from those of the adult controls. Most of these shape differences reflect general allometric size increase, but the liver and spleen of the transgenics undergo special enlargement or growth. These results indicate that the primary effect of elevated GH and IGF-I levels is increased overall growth, but in the relative proportions set by the intrinsic controls of individual organs and body regions.