Multifunctional wearable devices for diagnosis and therapy of movement disorders
Multifunctional wearable devices for diagnosis and therapy of movement disorders
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DOI：
10.1038/nnano.2014.38
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发表时间：
2014-05-01
影响因子：
38.3
通讯作者：
Kim, Dae-Hyeong
中科院分区：
文献类型：
--
作者：
Son, Donghee;Lee, Jongha;Kim, Dae-Hyeong
监测肌肉活动、存储数据和提供反馈治疗的可穿戴系统是个性化医疗和医疗保健的下一个前沿。然而，诸如与软组织紧密机械接触的高性能、节能传感器和存储器模块的制造以及治疗剂的受控递送等技术挑战限制了此类系统的大规模采用。在这里，我们描述的材料，力学和设计的多功能，可穿戴的皮肤系统，解决这些挑战，通过单片集成的纳米膜制造的自上而下的方法，纳米粒子组装自下而上的方法，和可拉伸的电子产品上的组织状聚合物基板。这种系统的代表性实例包括生理传感器、非易失性存储器和药物释放致动器。对电子、机械、传热和药物扩散特性的定量分析可验证各个组件的操作，从而实现系统级多功能性。
Wearable systems that monitor muscle activity, store data and deliver feedback therapy are the next frontier in personalized medicine and healthcare. However, technical challenges, such as the fabrication of high-performance, energy-efficient sensors and memory modules that are in intimate mechanical contact with soft tissues, in conjunction with controlled delivery of therapeutic agents, limit the wide-scale adoption of such systems. Here, we describe materials, mechanics and designs for multifunctional, wearable-on-the-skin systems that address these challenges via monolithic integration of nanomembranes fabricated with a top-down approach, nanoparticles assembled by bottom-up methods, and stretchable electronics on a tissue-like polymeric substrate. Representative examples of such systems include physiological sensors, non-volatile memory and drug-release actuators. Quantitative analyses of the electronics, mechanics, heat-transfer and drug-diffusion characteristics validate the operation of individual components, thereby enabling system-level multifunctionalities.