Risk of influenza A (H5N1) infection among poultry workers, Hong Kong, 1997-1998
Risk of influenza A (H5N1) infection among poultry workers, Hong Kong, 1997-1998
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DOI：
10.1086/340044
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发表时间：
2002-04-15
影响因子：
6.4
通讯作者：
Katz, JM
中科院分区：
文献类型：
--
作者：
Bridges, CB;Lim, W;Katz, JM
1997年，在家禽中爆发高致病性甲型流感（H5N1）的同时，有18例记录在案的人类H5N1病例。虽然接触活禽与人类疾病有关，但在家禽工人中没有病例记录。为评估H5N1禽传人的可能性，在293名参与家禽扑杀行动的香港政府工作人员和1525名工作人员中进行了一项队列研究。从GWs采集的成对血清样品和从PWs采集的单一血清样品如果通过微量中和和Western印迹测试均为阳性，则被认为是抗H5抗体阳性。在GWs中，3%血清阳性，1例血清转化。在PWs中，约10%有抗H5抗体。较密集的家禽接触，如屠宰和接触病禽，与有抗H5抗体有关。这些发现表明，职业接触会增加感染禽流感的风险。
In 1997, outbreaks of highly pathogenic influenza A (H5N1) among poultry coincided with 18 documented human cases of H5N1 illness. Although exposure to live poultry was associated with human illness, no cases were documented among poultry workers (PWs). To evaluate the potential for avian-to-human transmission of H5N1, a cohort study was conducted among 293 Hong Kong government workers (GWs) who participated in a poultry culling operation and among 1525 PWs. Paired serum samples collected from GWs and single serum samples collected from PWs were considered to be anti-H5 antibody positive if they were positive by both micro-neutralization and Western blot testing. Among GWs, 3% were seropositive, and 1 seroconversion was documented. Among PWs, similar to10% had anti-H5 antibody. More-intensive poultry exposure, such as butchering and exposure to ill poultry, was associated with having anti-H5 antibody. These findings suggest an increased risk for avian influenza infection from occupational exposure.