The relationship between body composition and knee cartilage volume in healthy, middle-aged subjects
The relationship between body composition and knee cartilage volume in healthy, middle-aged subjects
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DOI：
10.1002/art.20791
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发表时间：
2005-02-01
影响因子：
--
通讯作者：
Ebeling, PR
中科院分区：
文献类型：
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作者：
Cicuttini, FM;Teichtahl, AJ;Ebeling, PR
Objective.虽然肥胖被广泛认为是膝关节骨关节炎的危险因素，但尚不清楚身体组成的各个组成部分，如肌肉和脂肪的质量和分布，是否与疾病的发展有关。本研究探讨了身体成分的措施对胫骨软骨体积的纵向变化的影响。身体成分，通过双X线吸收测定法评估，胫骨软骨体积，通过磁共振成像评估，在86名健康的男性和女性谁是中年的年龄。通过基线测量后2年对每个膝关节成像并确定胫骨软骨体积与基线的差异来评估胫骨软骨体积的变化。在调整混淆因素后，确定手臂、腿部和全身肌肉和脂肪质量与胫骨外侧和内侧软骨体积之间的相关性，以及2年内胫骨软骨体积的变化。肌肉质量和胫骨内侧软骨体积之间存在显著相关性，与年龄、性别、体重指数、胫骨面积和体力活动水平无关。虽然肌肉质量和胫骨外侧软骨体积之间存在正相关，但在调整混杂因素后，这种关系并不持久。在调整混杂因素后，2年内肌肉质量损失与胫骨内侧和外侧软骨损失增加相关。在调整混杂因素后，脂肪量与内侧或外侧胫骨软骨体积之间，或脂肪量与2年内内侧或外侧胫骨软骨体积变化之间均无明显关系。肌肉质量是中年健康人胫骨内侧软骨体积的独立预测因子，并与胫骨软骨丢失率降低相关。这表明，增加肌肉质量可能对骨关节炎的发病有保护作用。
Objective. Although obesity is widely accepted as a risk factor for knee osteoarthritis, it is not clear whether individual components of body composition, such as the mass and distribution of muscle and fat, are associated with development of the disease. This study examined the effect of measures of body composition on the longitudinal change in tibial cartilage volume.Methods. Body composition, assessed via dual x-ray absorptiometry, and tibial cartilage volume, assessed via magnetic resonance imaging, were measured in 86 healthy men and women who were mid-life in age. Change in tibial cartilage volume was assessed by imaging each knee 2 years after the baseline measurement and determining the difference from baseline in tibial cartilage volume. Correlations were determined between the muscle and fat mass of the arm, leg, and total body and the volume of the lateral- and medialtibial cartilage, as well as the change in tibial cartilage volume over 2 years, after adjusting for confounders.Results. There was a significant association between muscle mass and the medial-tibial cartilage volume, independent of age, sex, body mass index, tibial bone area, and level of physical activity. Although there was a positive association between muscle mass and the lateral-tibial cartilage volume, this did not persist after adjustment for confounders. Loss of muscle mass was associated with an increased loss of medial- and lateraltibial cartilage over 2 years, after adjusting for confounders. No relationship was apparent between fat mass and either medial- or lateral-tibial cartilage volume, or between fat mass and change in either medial- or lateral-tibial cartilage volume over 2 years, after adjusting for confounders.Conclusion. Muscle mass is an independent predictor of medial-tibial cartilage volume in healthy people in mid-life and is associated with a reduction in the rate of loss of tibial cartilage. This suggests that increased muscle mass may be protective against the onset of osteoarthritis.