On the occurrence of the fenestrated vessels in Wallerian degeneration of the peripheral nerve
On the occurrence of the fenestrated vessels in Wallerian degeneration of the peripheral nerve
复制标题
周围神经华勒变性中有窗血管的发生
DOI：
10.1007/bf00690205
复制
发表时间：
2004
影响因子：
12.7
通讯作者：
F. Ikuta
中科院分区：
文献类型：
--
作者：
Shinji Ohara;F. Ikuta
本文对小鼠膈神经夹伤后远段的超微结构进行了研究。在对照组中，神经内膜仅含有无孔毛细血管。在实验中，从第2天到第6天，神经内膜毛细血管偶尔出现穿孔，其细胞质变薄。在这个阶段，轴突变性和髓鞘破坏变得明显，显示沃勒变性的早期阶段。此外，还观察到伴随巨噬细胞侵入的邻近内皮细胞的脱离。这些发现是以前未观察到的变化，神经内膜内皮细胞在沃勒变性。并对窗孔早期出现的意义作了简要讨论。
Ultrastructural studies were made on the distal segments of the mouse phrenic nerve after crush injury. In the control, endoneurium contained only unfenestrated capillaries. In the experiment, from day 2 to day 6, endoneurial capillaries occasionally showed fenestrations with the attenuation of its cytoplasm. At this stage, axonal degeneration and myelin breakdown became evident showing early stage of Wallerian degeneration. In addition, detachment of the neighboring endothelial cells concomitant with the invasion of macrophage was also observed. These findings were previously unobserved changes of the endoneurial endothelium in Wallerian degeneration. The significance of the early occurrence of fenestrae was discussed briefly.