Cardiac and pulmonary oxidative stress in rats exposed to realistic emissions of source aerosols.
Cardiac and pulmonary oxidative stress in rats exposed to realistic emissions of source aerosols.
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暴露于源气溶胶现实排放的大鼠的心脏和肺氧化应激。
DOI：
10.3109/08958378.2011.601433
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发表时间：
2011-08
影响因子：
2.1
通讯作者：
Gonzalez-Flecha B
中科院分区：
文献类型：
--
作者：
Lemos M;Diaz EA;Gupta T;Kang CM;Ruiz P;Coull BA;Godleski JJ;Gonzalez-Flecha B
体内化学发光(CL)是对组织中活性氧物种的一种测量。CL被用来评估美国三个燃煤电厂的老化排放所产生的吸入气雾剂对肺和心脏的反应。SD大鼠暴露于过滤空气或：(1)初级排放(P)；(2)臭氧氧化排放(PO)；(3)氧化排放+二次有机气溶胶(POS)；(4)中和氧化排放+二次有机气溶胶(PONS)；(5)对照情景：氧化排放+无初级颗粒物(OS)、单独氧化排放(O)和仅SOA(S)。染毒6小时后，立即测定肺和心脏的CL含量。同时检测组织中硫代巴比妥酸反应物质(TBARS)。暴露在P或PO气雾剂中，与任何单个工厂或合并所有数据时肺或心脏CL中的过滤空气相比，没有引起任何变化。POS只在一家工厂导致肺CL和TBARS显著增加，而不是在所有工厂的综合数据中；PONS仅在来自所有工厂的数据合并时才导致肺CL增加。仅当来自所有植物的数据结合在一起时，暴露于POS的心脏CL也显著增加。在有TBARS积累的植株中，PONS显著增加了心脏CL，但在联合数据中没有显著增加。暴露于O、OS和S没有CL效应。对暴露环境中个别测量成分的单变量分析没有发现任何与CL增加相关的成分。这些数据表明，燃煤发电厂的排放与其他大气成分结合在一起，会产生有限的肺和心脏氧化应激。
In vivo chemiluminescence (CL) is a measure of reactive oxygen species in tissues. CL was used to assess pulmonary and cardiac responses to inhaled aerosols derived from aged emissions of three coal-fired power plants in the USA. Sprague–Dawley rats were exposed to either filtered air or: (1) primary emissions (P); (2) ozone oxidized emissions (PO); (3) oxidized emissions + secondary organic aerosol (SOA) (POS); (4) neutralized oxidized emissions + SOA (PONS); and (5) control scenarios: oxidized emissions + SOA in the absence of primary particles (OS), oxidized emissions alone (O), and SOA alone (S). Immediately after 6 hours of exposure, CL in the lung and heart was measured. Tissues were also assayed for thiobarbituric acid reactive substances (TBARS). Exposure to P or PO aerosols led to no changes compared to filtered air in lung or heart CL at any individual plant or when all data were combined. POS caused significant increases in lung CL and TBARS at only one plant, and not in combined data from all plants; PONS resulted in increased lung CL only when data from all plants were combined. Heart CL was also significantly increased with exposure to POS only when data from all plants were combined. PONS increased heart CL significantly in one plant with TBARS accumulation, but not in combined data. Exposure to O, OS, and S had no CL effects. Univariate analyses of individual measured components of the exposure atmospheres did not identify any component associated with increased CL. These data suggest that coal-fired power plant emissions combined with other atmospheric constituents produce limited pulmonary and cardiac oxidative stress.
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影响因子：
1.9
作者：
Coull BA
通讯作者：
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影响因子：
3.8
作者：
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通讯作者：
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作者：
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通讯作者：
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作者：
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通讯作者：
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影响因子：
10.4
作者：
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通讯作者：
González-Flecha B