Non-Gaussian diffusion MR imaging of glioma: comparisons of multiple diffusion parameters and correlation with histologic grade and MIB-1 (Ki-67 labeling) index
Non-Gaussian diffusion MR imaging of glioma: comparisons of multiple diffusion parameters and correlation with histologic grade and MIB-1 (Ki-67 labeling) index
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DOI：
10.1007/s00234-015-1606-5
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发表时间：
2016-02-01
期刊：
影响因子：
2.8
通讯作者：
Yao Zhenwei
中科院分区：
文献类型：
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作者：
Ren Yan;Pang Haopeng;Yao Zhenwei
本研究旨在比较高斯和非高斯磁共振成像（MRI）衍生参数与组织学分级和MIB-1的相关性。脑胶质瘤的Ki-67标记指数（MI）：65例经病理证实的胶质瘤患者，进行弥散加权MRI，2 B值（0，1000 s/mm（2））和22个B值（a千分之一货币符号5000 s/mm（2）），分别分为3组：II级（n = 35）、III级（n = 8）和IV级（n = 22）。比较两组的表观扩散系数（ADC）、慢扩散系数（Dslow）、分布扩散系数（DDC）和异质性指数α。进行受试者工作特征（ROC）曲线分析，以最大化区分III + IV级（高级别胶质瘤，HGG）和II级（低级别胶质瘤，LGG）以及IV级（多形性胶质母细胞瘤，GBM）和II + III级（其他级别胶质瘤，OGG）的曲线下面积（AUC）。分析MRI参数与MI的相关性，在肿瘤区域，ADC、Dslow、DDC和α值在II级中显著升高。（分别为1.37 +/- 0.29、0.70 +/- 0.11、1.39 +/- 0.34）（x10（-3）mm（2）/s）和0.88 +/- 0.05），而III级[（分别为0.99 +/- 0.13、0.55 +/- 0.07、1.04 +/- 0.20）（x10（-3）mm（2）/s）和0.80 +/- 0.03）和IV级[（1.03 +/- 0.14，0.50 +/- 0.05，1.02 +/- 0.16）（x10（-3）mm（2）/s）和0.76 +/- 0.04）（均P < 0.001）。参数α在区分HGG和LGG以及GBM和OGG时显示出最高AUC，分别为0.950和0.922。MRI参数与组织学分级和MI相关，非高斯MRI参数α和Dslow在胶质瘤分级方面上级ADC，可作为无创性预测胶质瘤恶性程度的可靠指标。
This study was conducted to compare the association of Gaussian and non-Gaussian magnetic resonance imaging (MRI)-derived parameters with histologic grade and MIB-1 (Ki-67 labeling) index (MI) in brain glioma.Sixty-five patients with pathologically confirmed glioma, who underwent diffusion-weighted MRI with 2 b values (0, 1000 s/mm(2)) and 22 b values (a parts per thousand currency sign5000 s/mm(2)), respectively, were divided into three groups of grade II (n = 35), grade III (n = 8), and grade IV (n = 22). Comparisons by two groups were made for apparent diffusion coefficient (ADC), slow diffusion coefficient (Dslow), distributed diffusion coefficient (DDC), and heterogeneity index alpha. Analyses of receiver operating characteristic (ROC) curve were performed to maximize the area under the curve (AUC) for differentiating grade III + IV (high-grade glioma, HGG) from grade II (low-grade glioma, LGG) and grade IV (glioblastoma multiforme, GBM) from grade II + III (other grade glioma, OGG). Correlations with MI were analyzed for the MRI parameters.On tumor regions, the values of ADC, Dslow, DDC, and alpha were significantly higher in grade II [(1.37 +/- 0.29, 0.70 +/- 0.11, 1.39 +/- 0.34) (x10(-3) mm(2)/s) and 0.88 +/- 0.05, respectively] than in grade III [(0.99 +/- 0.13, 0.55 +/- 0.07, 1.04 +/- 0.20) (x10(-3) mm(2)/s) and 0.80 +/- 0.03, respectively] and grade IV [(1.03 +/- 0.14, 0.50 +/- 0.05, 1.02 +/- 0.16) (x10(-3) mm(2)/s) and 0.76 +/- 0.04, respectively] (all P < 0.001). The parameter alpha showed the highest AUCs of 0.950 and 0.922 in discriminating HGG from LGG and GBM from OGG, respectively. Significant correlations with histologic grade and MI were observed for the MRI parameters.The non-Gaussian MRI-derived parameters alpha and Dslow are superior to ADC in glioma grading, which are comparable with ADC as reliable biomarkers in noninvasively predicting the proliferation level of glioma malignancy.