Association of occupational noise exposure, bilateral hearing loss with atherosclerotic cardiovascular disease risk in Chinese adults
Association of occupational noise exposure, bilateral hearing loss with atherosclerotic cardiovascular disease risk in Chinese adults
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中国成人职业噪声暴露、双侧听力损失与动脉粥样硬化性心血管疾病风险的关系
DOI：
10.1016/j.ijheh.2021.113776
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发表时间：
2021-05-29
影响因子：
6
通讯作者：
Chen, Weihong
中科院分区：
文献类型：
--
作者：
Wang, Dongming;Xiao, Yang;Chen, Weihong
我们的目的是探讨中国成年人职业噪声暴露与动脉粥样硬化性心血管疾病（ASCVD）风险的关系。我们纳入了东风-同济队列研究的 21,412 名参与者，通过工作场所噪声水平和/或职位来评估职业噪声暴露，听力损失定义为任何耳朵在 0.5、1、2 和 4 kHz 的纯音平均值为 25 dB 或更高。与没有职业性噪声暴露的参与者相比，在调整潜在混杂因素后，噪声暴露持续时间≥20年的10年ASCVD风险显着更高（OR = 1.20，95%CI = 1.05-1.32）。在亚组分析中，该关联仅在男性（OR = 1.86，95% CI = 1.12-3.14）和年龄等于或大于60岁的参与者（OR = 1.20，95% CI = 1.05-1.33）中具有统计学意义，但在女性（OR = 1.15，95% CI = 0.71-1.92）和年龄在60岁以下的参与者中不具有统计学意义。 （OR = 1.51，95%CI = 0.75-2.85）。在子样本分析中（N = 10,165），双侧听力损失与 10 年 ASCVD 的较高风险相关（OR = 1.72，95%CI = 1.30-2.30），特别是对于男性参与者（OR = 2.40，95%CI = 1.61-3.42）和年龄等于或超过 60 岁的参与者（OR = 1.85，95%CI = 1.30-2.30） = 1.40-2.44）。本研究表明，职业噪声暴露可能是 ASCVD 的潜在危险因素，特别是对于男性和老年参与者。
We aimed to explore the association of occupational noise exposure with atherosclerotic cardiovascular disease (ASCVD) risk in Chinese adults. We included 21,412 participants from the Dongfeng-tongji Cohort Study, occupational noise exposure was evaluated through workplace noise level and/or the job titles, hearing loss was defined as a pure-tone mean of 25 dB or higher at 0.5, 1, 2, and 4 kHz in any ear. Compared with participants without occupational noise exposure, the 10-year ASCVD risk was significantly higher for noise exposure duration >= 20 years (OR = 1.20, 95%CI = 1.05-1.32) after adjusting for potential confounders. In the subgroup analysis, the association was only statistically significant in males (OR = 1.86, 95%CI = 1.12-3.14) and participants aged equal to or over 60 years old (OR = 1.20, 95%CI = 1.05-1.33), but not in females (OR = 1.15, 95% CI = 0.71-1.92) and aged below 60 (OR = 1.51, 95%CI = 0.75-2.85). In the subsample analyses (N = 10,165), bilateral hearing loss was associated with a higher risk of 10-year ASCVD (OR = 1.72, 95%CI = 1.30-2.30), especially for participants who were males (OR = 2.40, 95%CI = 1.61-3.42) and aged equal to or over 60 (OR = 1.85, 95%CI = 1.40-2.44). The present study suggests that occupational noise exposure may be a potential risk factor for ASCVD, especially for males and older participants.