Low-density lipoprotein level on admission is not associated with postintravenous thrombolysis intracranial hemorrhage in patients with acute ischemic stroke
Low-density lipoprotein level on admission is not associated with postintravenous thrombolysis intracranial hemorrhage in patients with acute ischemic stroke
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DOI：
10.1136/jim-2018-000827
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发表时间：
2019-03-01
影响因子：
2.6
通讯作者：
Chan, Lung
中科院分区：
文献类型：
--
作者：
Hong, Chien Tai;Chiu, Wei Ting;Chan, Lung
组织型纤溶酶原激活剂（tPA）静脉溶栓是急性缺血性卒中的金标准。然而，由于tPA后颅内出血（ICH）的担忧，其应用受到限制。低密度脂蛋白（LDL）被认为会增加缺血性卒中后出血性转化的风险。然而，LDL是否与tPA后ICH相关仍存在争议。本研究获得了双河医院的病历，并回顾性审查了2009年8月至2016年12月期间的病例，以研究LDL与tPA后ICH风险之间的相关性。采用Student t检验、Fisher精确检验、单变量和逐步多元回归模型以及p
Intravenous thrombolysis with the tissue plasminogen activator (tPA) is the gold standard for acute ischemic stroke. However, its application is limited because of the concern of the post-tPA intracranial hemorrhage (ICH). Low low-density lipoprotein (LDL) has been speculated to increase the risk of hemorrhagic transformation after ischemic stroke. However, whether LDL is associated with post-tPA ICH remains controversial. The present study obtained the medical records from Shuang Ho Hospital and retrospectively reviewed for the period between August 2009 and December 2016 to investigate the association between LDL and the risk of post-tPA ICH. The differences were analyzed using the Student's t-test, Fisher's exact test, the univariate and stepwise multiple regression model, and p