Identification of cells expressing T and p28,33 (Ia-like) antigens in sections of human chronic inflammatory periodontal disease.
Identification of cells expressing T and p28,33 (Ia-like) antigens in sections of human chronic inflammatory periodontal disease.
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人类慢性炎症性牙周病切片中表达 T 和 p28,33（Ia 样）抗原的细胞的鉴定。
DOI：
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发表时间：
1980
影响因子：
3.5
通讯作者：
M. Greaves
中科院分区：
文献类型：
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作者：
G. Seymour;M. Greaves
以往的研究表明，在进行性人类慢性炎症性牙周病中存在的淋巴细胞可能是B细胞来源的。本研究旨在确定淋巴细胞分化抗原的特异性抗血清在慢性炎症病变中原位识别细胞亚群的有用性。鉴定了HuTLA+（5-10%）和p28，33+（90-95%）细胞。虽然p28，33+细胞群可能包括巨噬细胞和T细胞亚群，但大多数细胞可能是B细胞来源的。这支持了早期的建议，即人类进行性牙周病是一种B细胞病变，并表明，在免疫荧光试验中的淋巴细胞分化抗原的抗血清将描绘细胞亚群原位在慢性炎症性病变。
Previous studies have indicated that the lymphocytes present in progressive human chronic inflammatory periodontal disease may be of B-cell origin. The present investigation was undertaken to determine the usefulness of specific antisera to lymphocyte differentiation antigens in identifying the cell subpopulations in situ in the chronic inflammatory lesion. Both HuTLA+ (5–10%) and p28,33+ (90–95%) cells were identified. Although the p28,33+ population may include macrophages and a subset of T-cells, the majority of cells are probably of B-cell origin. This supports earlier suggestions that progressive periodontal disease in humans is a B-cell lesion and demonstrates that antisera to lymphocyte differentiation antigens in an immunofluorescence assay will delineate cell subpopulations in situ in a chronic inflammatory lesion.