A novel endoscopic visible full-thickness cryoablation device on stomach
A novel endoscopic visible full-thickness cryoablation device on stomach
复制标题
一种新型内镜可见胃全层冷冻消融装置
DOI：
10.1038/s41598-020-61595-x
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发表时间：
2020-03
影响因子：
4.6
通讯作者：
Liu Jie
中科院分区：
文献类型：
--
作者：
Liu Yao;Zheng Wanwei;Tseng Yujen;Zhang Jun;Li Wenshuai;Wang Bangting;Pan Yida;Zhu Jie;Luo Zhongguang;Luo Feifei;Liu Jie
冷冻消融已用于治疗各种内脏实体肿瘤，但在内镜下治疗胃肿瘤，在消融部位、冷冻深度和有效温度的精确控制方面鲜有报道。因此，我们开发了一种新颖的设备，可以通过内窥镜对胃进行精确的冷冻消融。本研究旨在评估该装置对猪胃的有效性和安全性。结果表明，这种新型装置可以直接观察手术空间，从而可以准确、安全地进行胃消融。三分钟的冷冻消融造成了直径 1 厘米的透壁胃损伤。在浆膜侧，中心温度分别降至-64.2℃、-34.1℃、26.1℃，距中心1cm和2cm。组织病理学显示细胞急性破裂，粘膜腺体受损，固有肌层部分破坏，浆膜有轻微渗出。三个月后，疤痕形成，胃结构完全恢复。未观察到胃活动性出血或穿孔，也未观察到邻近器官损伤或粘连。这种内窥镜冷冻消融装置可以在有效温度下安全、全层冷冻消融，这可能为胃肿瘤提供另一种治疗方法。
Cryoablation has been used for the treatment of various sorts of solid visceral tumors, but few are reported on gastric tumor via endoscope, in terms of accurate control of ablation site, freezing depth and effective temperature. Thus, we developed a novel device, which could perform accurate cryoablation on the stomach via endoscope. This study aimed to evaluate the efficacy and safety of the device on porcine stomach. Results showed that the novel device could provide direct view of the operation space, allowing accurate and safe ablation of the stomach. Three minutes cryoablation caused a transmural, 1 cm radius gastric lesion. On serosal side, the temperature dropped to −64.2 °C, −34.1 °C, 26.1 °C at the center, 1 cm and 2 cm from center, respectively. Histopathology revealed acute ruptured cells with damaged glands in mucosa, partial disruption in muscularis propria and serosal slight exudation. Three months later, scar formed with complete recovery of gastric structure. No active bleeding or perforation of stomach, nor injury or adhesion of adjacent organs was observed. This endoscopic cryoablation device allowed safe, full-thickness cryoablation with effective temperature, which may provide an alternative treatment for gastric tumor.
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DOI：
--
发表时间：
2004
期刊：
Reviews in urology
影响因子：
--
作者：
Jeffrey K. Cohen
通讯作者：
Jeffrey K. Cohen
影响因子：
2.7
作者：
E. Breitbart
通讯作者：
E. Breitbart
DOI：
10.5992/ajcs-d-12-00031.1
发表时间：
2012-09
期刊：
The American Journal of Cosmetic Surgery
影响因子：
--
作者：
J. Petro
通讯作者：
J. Petro
影响因子：
2.7
作者：
Soule, Erik;Bandyk, Mark;Matteo, Jerry
通讯作者：
Matteo, Jerry
影响因子：
7.7
作者：
Cho, Sarah;Zanati, Simon;Marcon, Norman
通讯作者：
Marcon, Norman