Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan
Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan
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DOI：
10.1016/s1726-4901(10)70003-4
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发表时间：
2010-02-01
影响因子：
3
通讯作者：
Lee, Shou-Dong
中科院分区：
文献类型：
--
作者：
Chan, Yu-Jiun;Lee, Chia-Ling;Lee, Shou-Dong
背景：2009年H1N1流感大流行于2009年4月出现，并在全球迅速广泛传播。除了特定的抗病毒剂外，大规模接种疫苗被认为是控制传播的最有效方法。为了了解某些风险群体的疫苗接种前状态，本研究比较了具有不同接触风险的医院工作人员和普通人群中2009年H1N1流感病毒抗体的基线血清阳性率。方法：295份来自医院工作人员的血清样本和244份来自前来体检的人的对照血清样本（对照组）在大规模疫苗接种运动之前的2009年10月至2009年11月期间收集。根据潜在接触风险将医院工作人员分为一线风险人员（第1组）和二线风险人员（第2组）。进行血凝抑制（HI）试验以确定个体血清学状态。结果：医院工作人员和对照组的平均年龄和性别比（%男性）分别为36.9 ± 10.6岁和52.0 ± 12.6岁，分别为24.4%和57.6%。医护人员甲型H1N1流感病毒抗体阳性率（20.0%）明显高于对照组（2.9%）（p < 0.001）。此外，第1组的抗H1N1流感病毒SPR抗体显著高于第2组（30.8%对12.6%，p < 0.001）。结论：医院工作人员抗H1N1流感病毒抗体的SPR高于一般人群，反映了较高的接触风险。接种前监测不同风险群体的免疫状态可能有助于优先考虑哪些群体应该首先接种疫苗。[中华医学杂志2010;73（2）：62-66]
Background: The pandemic (H1N1) 2009 influenza emerged in April 2009 and spread rapidly and broadly all over the world. In addition to specific antiviral agents, massive vaccination is thought to be the most effective way of controlling the transmission. To understand the prevaccination status of certain risk groups, this study compared the baseline seroprevalence of antibodies to the pandemic (H1N1) 2009 influenza virus among hospital staff with different contact risks and that of the general population.Methods: A total of 295 serum samples from hospital staff and 244 control serum samples from people who came for physical check-up (control group) were collected between October 2009 and November 2009 before the massive vaccination campaign. The hospital staff was divided into first-line risk personnel (group 1) and second-line risk personnel (group 2) according to their potential contact risks. Hemagglutination-inhibition (HI) tests were conducted to determine the individual serological status. The seropositive rate (SPR, defined as the proportion with HI titers >= 1:40) of antibodies to H1N1 influenza virus and its geometric mean titer (GMT) were calculated and compared among the different groups.Results: The mean ages and sex ratio (% male) of the hospital staff and control groups were 36.9 +/- 10.6 years and 52.0 +/- 12.6 years, and 24.4% and 57.6%, respectively. The SPR of the antibodies to H1N1 influenza virus of the hospital staff was significantly higher than that of the control group (20.0% vs. 2.9%, p < 0.001). Furthermore, the SPR antibodies to H1N1 influenza virus of group 1 were significantly higher than that of group 2 (30.8% vs. 12.6%, p < 0.001). However, the GMT of antibodies to H1N1 influenza virus of the hospital staff was not significantly different from that of the control group (p=0.925).Conclusion: The SPR of antibodies against the pandemic (H1N1) 2009 virus in the hospital staff was higher than that in the general population, reflecting a higher contact risk. Prevaccination surveillance of the immune status of different risk groups may help to prioritize which groups should be vaccinated first. [J Chin Med Assoc 2010;73(2):62-66]