How is the development of dental biofilms influenced by the host?
How is the development of dental biofilms influenced by the host?
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DOI：
10.1111/j.1600-051x.2010.01673.x
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发表时间：
2011-03-01
影响因子：
6.7
通讯作者：
Devine, Deirdre A.
中科院分区：
文献类型：
--
作者：
Marsh, Philip D.;Devine, Deirdre A.
P>BackgroundThe host provides environmental conditions that support diverse communities of microbial on all environmentally exposed surfaces of the body.Materials and MethodsTo review the literature to determine which properties of the host substantially affect the development of dental biofilms.ResultsThe mouth facilitates the growth of a characteristic resident microbiota.口腔微生物群的组成受温度，pH值和大气以及宿主防御和宿主遗传学的影响。此外，宿主还提供内源性营养物质和各种表面以形成生物膜。在健康状况下，口腔内的微生物与宿主形成共生关系，并受到宿主-微生物交互作用的调节。这种居民的微生物群是敏感的扰动在宿主环境中，特别是在营养供应和pH值的变化，使以前的微生物的小组件可以变得更具竞争力（反之亦然），导致在重组的生物膜群落structure.ConclusionThe宿主环境决定的居民微生物群的组成和基因表达。口腔环境条件的变化会破坏宿主与其常驻微生物之间的正常共生关系，并增加疾病的风险。
P>BackgroundThe host provides environmental conditions that support diverse communities of microorganisms on all environmentally-exposed surfaces of the body.Materials and MethodsTo review the literature to determine which properties of the host substantially influence the development of dental biofilms.ResultsThe mouth facilitates the growth of a characteristic resident microbiota. The composition of the oral microbiota is influenced by temperature, pH, and atmosphere, as well as by the host defences and host genetics. In addition, the host supplies endogenous nutrients and a variety of surfaces for biofilm formation. In health, the resident oral microbiota forms a symbiotic relationship with the host, regulated by active host-microbe cross talk. This resident microbiota is sensitive to perturbations in the host environment, especially to changes in nutrient supply and pH, so that previously minor components of the microbiota can become more competitive (and vice versa), resulting in reorganization of biofilm community structure.ConclusionThe host environment dictates the composition and gene expression of the resident microbiota. Changes in oral environmental conditions can disrupt the normal symbiotic relationship between the host and its resident microbes, and increase the risk of disease.