Toward Preventing Speech and Language Disorders of Known Genetic Origin: First Post-Intervention Results of Babble Boot Camp in Children With Classic Galactosemia.
Toward Preventing Speech and Language Disorders of Known Genetic Origin: First Post-Intervention Results of Babble Boot Camp in Children With Classic Galactosemia.
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DOI：
10.1044/2021_ajslp-21-00098
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发表时间：
2021-11-04
影响因子：
2.6
通讯作者：
Potter, Nancy
中科院分区：
文献类型：
--
作者：
Peter, Beate;Davis, Jennifer;Cotter, Sarah;Belter, Alicia;Williams, Emma;Stumpf, Melissa;Bruce, Laurel;Eng, Linda;Kim, Yookyung;Finestack, Lizbeth;Stoel-Gammon, Carol;Williams, Delaney;Scherer, Nancy;VanDam, Mark;Potter, Nancy
Babble靴子Camp（BBC）是一套积极主动的活动和程序，旨在预防婴儿在可预测的风险中出现言语和语言障碍。它是通过家长培训实施的，目前正在对新生儿诊断为经典半乳糖血症（CG）的儿童进行临床试验，这是一种具有高风险的言语和语言障碍的代谢性疾病。本研究的目的是提供更新以前的试点研究，并提出了第一套干预后的结果。干预和数据收集发生在儿童年龄< 6-24个月期间，并在2.5岁和3.5岁时对言语和语言进行随访评估。治疗目标包括最早发声率、牙牙学语复杂性、言语产生准确性以及词汇和句法增长。年龄最大的15名CG儿童（包括3名未经治疗的对照组）完成了第一组随访评估。17名接受治疗的CG儿童、6名未经治疗的CG儿童和6名典型对照儿童的汇总数据长达10个月。在7-9个月大时，用平均牙牙学语水平测量的牙学语复杂性，在治疗的CG儿童中高于未治疗的CG儿童和典型对照组。在24个月大之前，接受CG治疗的儿童比未接受治疗的对照组具有更大的表达性但不接受性词汇量。随访测试显示，所有12个治疗的儿童与CG和典型的清晰度分数为11这些典型的语言分数，而三个未治疗的儿童与CG有低清晰度和表达性语言分数。BBC似乎是一种可行的干预措施，以支持GC儿童的言语和表达性语言发展。未来的研究将评估最早和最晚的BBC组件的结果的相对贡献。
Babble Boot Camp (BBC) is a package of proactive activities and routines designed to prevent speech and language disorders in infants at predictable risk. It is implemented via parent training and currently undergoing clinical trial in children with a newborn diagnosis of classic galactosemia (CG), a metabolic disease with high risk of speech and language disorders. The purpose of this study is to provide updates to a previous pilot study and to present the first set of post-intervention results. The intervention and data collection occurred during child ages < 6–24 months, with follow-up assessments of speech and language at ages 2.5 and 3.5 years. Treatment targets included earliest vocalization rates, babble complexity, speech production accuracy, and vocabulary and syntactic growth. The oldest 15 children with CG (including three untreated controls) completed the first set of follow-up assessments. Aggregate data up to 10 months were available for 17 treated children with CG, six untreated children with CG, and six typical controls. At ages 7–9 months, babbling complexity, as measured with mean babbling level, was higher in the treated children with CG than in the untreated children with CG and the typical controls. Prior to 24 months of age, the treated children with CG had greater expressive but not receptive vocabulary sizes than an untreated control. Follow-up testing showed typical language scores for all 12 treated children with CG and typical articulation scores for 11 of these, whereas one of three untreated children with CG had low articulation and expressive language scores. The BBC appears to be a viable intervention to support the speech and expressive language development of children with GC. Future studies will evaluate the relative contributions of the earliest and later BBC components to outcomes.