INCREASED ENERGY-EXPENDITURE IN PARKINSONS-DISEASE
INCREASED ENERGY-EXPENDITURE IN PARKINSONS-DISEASE
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DOI：
10.1136/bmj.301.6763.1256
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发表时间：
1990-12-01
影响因子：
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通讯作者：
TOMKINS, A
中科院分区：
文献类型：
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作者：
LEVI, S;COX, M;TOMKINS, A
我们已经注意到，与其他受试者相比，帕金森病患者往往较瘦，但除了最近的报告外，文献中没有记录这种观察结果。“如果饮食摄入和能量消耗之间存在差异，体重减轻是可以预期的。鉴于相当大的变化，肌张力andinvoluntary运动的特点是帕金森氏病患者，我们调查了能量消耗的患者治疗前和治疗后，他们的diseases.Patients，方法和结果14例帕金森氏病患者进行了研究（9名女性和5名男性，平均年龄76-4（SE 5 - 8）岁）。还研究了16名健康老年志愿者（11名女性和5名男性，平均年龄76-5（9-0）岁）。该方案得到了医学院伦理委员会的批准。帕金森病患者的体重低于健康受试者（60 9（10-8）kg v 66-8（12 6）kg）。帕金森病患者的瘦体重也较轻，根据皮褶测量计算（46 6（7-6）kg v 50 2（11 2）kg），2但这些差异无统计学意义。通过间接量热法使用通风罩技术测量静息能量消耗，其中将透明丙烯酸罩放置在受试者的头部和肩部上，并从罩中连续吸入呼出的空气;
We have noted that patients with Parkinson's disease tend to be thin compared with other subjects but, apart from a recent report, this observation is not recorded in the literature.'Weight loss is to be expected if there is a discrepancy between dietary intake and energy expen-diture. In view of the considerable changes in muscular tone andinvoluntary movements that are characteristic of patients with Parkinson's disease we investigated energy expenditure in patients before and after treatment for their disease.Patients, methods, and results Fourteen patients with Parkinson's disease were studied (9 women and 5 men, mean age 76-4 (SE 5 8) years). Sixteen healthy elderly volunteers (iI women and 5 men, mean age 76-5 (9-0) years) were also studied. The protocol was approved by the ethical committee of the school of medicine. Patients with Parkinson's disease weighed less than healthy subjects (60 9 (10-8) kg v 66-8 (12 6) kg). Patients with Parkinson's disease also had less lean body mass, calculated from skinfold measurements (46 6 (7-6) kg v 50 2 (11 2) kg), 2 but these differences were not statistically significant. Resting energy expenditure was measured by indirect calorimetry using a ventilated hood technique in which a transparent acrylic hood is placed over the subject's head and shoulders and expired air is sucked from the hood continuously; the concentrations of