Cleaning House: Selective Autophagy of Organelles.
Cleaning House: Selective Autophagy of Organelles.
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DOI：
10.1016/j.devcel.2017.02.016
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发表时间：
2017-04-10
影响因子：
11.8
通讯作者：
Baehrecke EH
中科院分区：
文献类型：
--
作者：
Anding AL;Baehrecke EH
自噬对细胞器的选择性清除对于从酵母到人类的生物体中的细胞稳态的调节是至关重要的。去除受损的细胞器清除了细胞中潜在的有毒副产物，并使细胞器组分能够重新用于生物能量学。因此，细胞器清除的缺陷可能对细胞的健康有害，导致癌症、神经变性和炎性疾病。细胞器特异性自噬可以清除线粒体、过氧化物酶体、溶酶体、内质网、叶绿体和细胞核。在这里，我们回顾了我们的理解的机制，调节细胞器的清除自噬和突出的差距，我们的知识，这些过程。自噬对细胞器的选择性清除对于从酵母到人类的生物体中的细胞稳态的调节是至关重要的。细胞器清除的缺陷可能是有害的，并导致癌症、神经变性和炎性疾病。Anding和Baehrecke回顾了对自噬调节细胞器清除的理解。
The selective clearance of organelles by autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. Removal of damaged organelles clears the cell of potentially toxic byproducts and enables reuse of organelle components for bioenergetics. Thus, defects in organelle clearance may be detrimental to the health of the cells, contributing to cancer, neurodegeneration and inflammatory diseases. Organelle-specific autophagy can clear mitochondria, peroxisomes, lysosomes, endoplasmic reticulum, chloroplasts and the nucleus. Here, we review our understanding of the mechanisms that regulate the clearance of organelles by autophagy and highlight gaps in our knowledge of these processes. The selective clearance of organelles by autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. Defects in organelle clearance can be detrimental and contribute to cancer, neurodegeneration and inflammatory diseases. Anding and Baehrecke review the understanding of the regulation of organelles clearance by autophagy.