Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to
Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to
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DOI：
10.18632/aging.100461
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发表时间：
2012-05-01
期刊：
影响因子：
5.2
通讯作者：
Blagosklonny, Mikhail V.
中科院分区：
文献类型：
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作者：
Blagosklonny, Mikhail V.
热量限制（CR）可以使营养感应mTOR通路失活，减缓衰老并预防年龄相关疾病，如II型糖尿病。与CR相比，雷帕霉素更有效地抑制mTOR。值得注意的是，严重的CR和饥饿会导致一种可逆的疾病，称为“饥饿糖尿病”。“正如已经讨论过的，长期给予雷帕霉素可以在一些动物模型中引起类似的情况。最近发表在《科学》杂志上的一篇论文报告说，雷帕霉素的长期治疗通过间接抑制mTOR复合物2在小鼠中引起糖尿病样疾病。在这里，我介绍了良性糖尿病的概念，并讨论了长期高剂量雷帕霉素治疗的饥饿样效应是否是其作为抗衰老药物的障碍。
Calorie restriction (CR), which deactivates the nutrient-sensing mTOR pathway, slows down aging and prevents age-related diseases such as type II diabetes. Compared with CR, rapamycin more efficiently inhibits mTOR. Noteworthy, severe CR and starvation cause a reversible condition known as "starvation diabetes." As was already discussed, chronic administration of rapamycin can cause a similar condition in some animal models. A recent paper published in Science reported that chronic treatment with rapamycin causes a diabetes-like condition in mice by indirectly inhibiting mTOR complex 2. Here I introduce the notion of benevolent diabetes and discuss whether starvation-like effects of chronic high dose treatment with rapamycin are an obstacle for its use as an anti-aging drug.