A unifying new model of cytokinesis for the dividing plant and animal cells
A unifying new model of cytokinesis for the dividing plant and animal cells
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DOI：
10.1002/bies.20559
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发表时间：
2007-04-01
期刊：
影响因子：
4
通讯作者：
Friml, Jiri
中科院分区：
文献类型：
--
作者：
Dhonukshe, Pankaj;Samaj, Jozef;Friml, Jiri
细胞分裂确保核质内容物正确地分配到两个子细胞中。一般认为，细胞质分裂在动物和植物中是不同的，因为在准备阶段的差异，进入中心体或无中心体的过程，刚性细胞壁的存在或不存在，以及基于“由外向内”或“由内向外”的机制。然而，这一长期存在的模式需要根据新的发现进一步重新评估。最近的进展表明，植物细胞，类似于动物细胞，具有调节细胞分裂平面的星形微管。此外，已发现内吞作用对于动物和植物细胞中的胞质分裂是重要的：含有内吞货物的囊泡为植物中的细胞板形成和动物中的中体通道的闭合提供材料。因此，虽然植物和动物细胞的细胞分裂过程的准备阶段不同，但后期阶段显示出相似性。我们将这些发现统一在一个模型中，该模型表明胞质分裂的保守模式。
Cytolkinesis ensures proper partitioning of the nucleocytoplasmic contents into two daughter cells. It has generally been thought that cytokinesis is accomplished differently in animals and plants because of the differences in the preparatory phases, into the centrosomal or acentrosomal nature of the process, the presence or absence of rigid cell walls, and on the basis of 'outside-in' or 'inside-out' mechanism. However, this long-standing paradigm needs further reevaluation based on new findings. Recent advances reveal that plant cells, similarly to animal cells, possess astral microtubuies that regulate the cell division plane. Furthermore, endocytosis has been found to be important for cytokinesis in animal and plant cells: vesicles containing endocytosed cargo provide material for the cell plate formation in plants and for closure of the midbody channel in animals. Thus, although the preparatory phases of the cell division process differ between plant and animal cells, the later phases show similarities. We unify these findings in a model that suggests a conserved mode of cytokinesis.