Membrane organization in immunoglobulin E receptor signaling.
Membrane organization in immunoglobulin E receptor signaling.
复制标题
免疫球蛋白 E 受体信号传导中的膜组织。
DOI：
10.1016/s1367-5931(99)80017-9
复制
发表时间：
1999
影响因子：
7.8
通讯作者：
Baird,B
中科院分区：
文献类型：
--
作者：
Sheets,ED;Holowka,D;Baird,B
质膜的结构和动力学被认为是高亲和力免疫球蛋白E受体信号转导的初始步骤的关键。最近的实验进展表明，高亲和力免疫球蛋白E受体和酪氨酸激酶Lyn与质膜内富含胆固醇和鞘脂的区域之间的相互作用对受体功能很重要。越来越多的证据表明，免疫球蛋白E受体信号的时空控制由质膜组织；一个有吸引力的假设是，配体依赖受体的聚集导致质膜上含lynn的有序区域与无序区域的分离。
The structure and dynamics of the plasma membrane are proposed to be critical for the initial steps of signal transduction by the high-affinity immunoglobulin E receptor. Recent experimental advances indicate that interactions between the high-affinity immunoglobulin E receptor and the tyrosine kinase Lyn with cholesterol- and sphingolipid-rich regions within the plasma membrane are important for receptor function. This accumulating evidence points to spatio-temporal control of immunoglobulin E receptor signaling by the organization of the plasma membrane; an attractive hypothesis is that ligand-dependent receptor aggregation causes the segregation of Lyn-containing ordered regions of the plasma membrane from disordered regions.