The effects of dieting and weight loss on neuroendocrine responses to tryptophan, clonidine, and apomorphine in volunteers. Important implications for neuroendocrine investigations in depression.
The effects of dieting and weight loss on neuroendocrine responses to tryptophan, clonidine, and apomorphine in volunteers. Important implications for neuroendocrine investigations in depression.
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节食和减肥对志愿者对色氨酸、可乐定和阿扑吗啡神经内分泌反应的影响。
DOI：
10.1001/archpsyc.1987.01800230032007
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发表时间：
1987
影响因子：
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通讯作者：
P. Cowen
中科院分区：
文献类型：
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作者：
G. Goodwin;C. Fairburn;P. Cowen
在志愿者中测定了静脉输注5-羟色胺前体色氨酸、α 2-肾上腺素受体激动剂盐酸可乐定和皮下注射多巴胺激动剂盐酸阿扑吗啡后在减肥饮食（1200 kcal/d）前和第3周中生长激素（GH）水平的增加。还测定了静脉输注色氨酸后催乳素水平的增加和对丙替瑞林的反应。在男性受试者中，GH反应色氨酸和阿扑吗啡显着增加节食，虽然也显着增加，可乐定的GH反应的影响要小得多。女性受试者对色氨酸和可乐定的GH反应显示出相似的趋势。在男性受试者中，催乳素对色氨酸和protirelin的反应并不因节食而增加。在女性中，催乳素对催乳素释放肽的反应同样没有增加，但催乳素对色氨酸的反应明显增强。这些结果与神经内分泌测试在抑郁症中的应用有关。此外，他们还提出了减肥对男性和女性神经递质功能的不同影响。
The increases in the growth hormone (GH) level following intravenous infusion of the 5-hydroxytryptamine precursor tryptophan, the alpha 2-adrenoceptor agonist clonidine hydrochloride, and subcutaneous injection of the dopamine agonist apomorphine hydrochloride were determined in volunteers before and in the third week of a weight-reducing diet (1200 kcal/d). The increases in the prolactin level following intravenous infusion of tryptophan and in response to protirelin were also determined. In male subjects, the GH responses to tryptophan and apomorphine were markedly increased by dieting; while also significantly increased, the GH responses to clonidine were much less affected. Female subjects showed similar trends in the GH responses to tryptophan and clonidine. In male subjects, prolactin responses to tryptophan and protirelin were not increased by dieting. In females, the prolactin response to protirelin was similarly not increased, but the prolactin response to tryptophan was markedly enhanced. These results are relevant to the use of neuroendocrine tests in depression. In addition, they suggest different effects of weight loss on neurotransmitter function in men and women.
重度抑郁症中的食欲障碍和过度内疚。
影响因子：
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作者：
Leckman,JF;Caruso,KA;Prusoff,BA;Weissman,MM;Merikangas,KR;Pauls,DL
通讯作者：
Pauls,DL
精神分裂症和主要情感障碍中生长激素和催乳素对阿扑吗啡的反应。
影响因子：
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作者：
Meltzer,HY;Kolakowska,T;Fang,VS;Fogg,L;Robertson,A;Lewine,R;Strahilevitz,M;Busch,D
通讯作者：
Busch,D
抑郁症中的肾上腺素能受体敏感性。
影响因子：
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作者：
Charney,DS;Heninger,GR;Sternberg,DE;Hafstad,KM;Giddings,S;Landis,DH
通讯作者：
Landis,DH