Generalized Q-space MRI reveals macroscopic patterns of tumor architecture in vivo.
Generalized Q-space MRI reveals macroscopic patterns of tumor architecture in vivo.
复制标题
DOI：
10.1109/nebec.2015.7117057
复制
发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Gilbert, Richard J
中科院分区：
文献类型：
--
作者：
Taylor, Erik N;Ding, Yao;Lin, Leon;Aninwene, George E 2nd;Hoffman, Matthew P;Fuller, Clifton D;Gilbert, Richard J
目前研究患者肿瘤活性的方法包括切除组织或活组织样本的分子特征。认识到肿瘤是由细胞及其环境的异质阵列组成的，有一个令人信服的理由来探索肿瘤组织的宏观组织。我们提出了一种利用广义Q空间MRI探测体内肿瘤微结构成分的新方法。该方法利用不同的磁场梯度和扩散灵敏度来获得质子扩散系数的体素尺度概率分布函数，然后利用跟踪成像绘制多体素细胞排列图。使用这种方法，我们描述了头颈癌患者的宏观组织特征，特别是描述了几何上连贯的外围区域和不连贯的核心区域之间的区域差异。这种方法可以包括一种用于评估体内肿瘤生物学属性并用于预测这种肿瘤对各种药物和干预的反应的方法。
Current approaches for studying tumor activity in patients involve molecular characterization in excised tissue or biopsied samples. Recognizing that tumors are composed of heterogeneous arrays of cells and their environment, there is a compelling rationale to explore the macroscopic organization of tumor tissue. We present a novel methodology for probing the micro-structural constituents of tumors in vivo utilizing generalized Q-space MRI. This approach employs varying magnetic field gradients and diffusion sensitivities to yield voxel-scale probability distribution functions of proton diffusivity, and then maps multi-voxel cellular alignment with tractography. Using this methodology, we describe the presence of macroscopic organizational features in patients with head and neck cancers, specifically depicting regional differences between the geometrically coherent periphery and incoherent core region. Such methods may comprise a method for assessing attributes of tumor biology in vivo and for predicting the response of such tumors to various drugs and interventions.