Changes in steroid metabolism among girls with precocious puberty may not be associated with urinary levels of bisphenol A
Changes in steroid metabolism among girls with precocious puberty may not be associated with urinary levels of bisphenol A
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DOI：
10.1016/j.reprotox.2013.03.008
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发表时间：
2014-04-01
影响因子：
3.3
通讯作者：
Chung, Bong Chul
中科院分区：
文献类型：
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作者：
Lee, Su Hyeon;Kang, Se Mi;Chung, Bong Chul
性早熟（PP）是指在异常早期出现青春期发育的身体和激素体征。对42例中央PP和40例外周PP患者的尿类固醇特征进行评估，以比较代谢变化。雄激素水平，如睾酮、雄烯二酮、雄烯二醇、16 α-羟基-脱氢表雄酮和5 α-雄烯二酮，在两个PP组中趋于高水平，17 β-雌二醇水平在中央PP组中更高（P
Precocious puberty (PP) refers to the appearance of physical and hormonal signs of pubertal development at an abnormally early age. Urinary steroid signatures obtained from 42 patients with central PP and 40 patients with peripheral PP were assessed to compare metabolic changes. Levels of androgens such as testosterone, androstenedione, androstenediol, 16 alpha-hydroxy-dehydroepiandrosterone, and 5 alpha-androstenedione tended to be high in both PP groups, and the level of 17 beta-estradiol was higher in the central-PP group (P